| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50eb752940fa4aa36756a6bc9f6f3504 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0368
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0393 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-5406 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715 |
| filingDate |
2015-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3ac78b0411b5a3e7484a026ea6f777f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_973ff7ce33b9c5f730a90445e1a94cfb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a22d49d1d61d486248bdb69b148c650
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa00dd6af648ceda74730ae1269bacc1 |
| publicationDate |
2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2656529-T3 |
| titleOfInvention |
Animals with humanized IL-4 and IL-4R alpha |
| abstract |
A rodent, which comprises a substitution of a genomic fragment of a rodent IL-4Rα gene in an endogenous rodent IL-4Rα locus with a genomic fragment of a human IL4-Rα gene to form an IL-4Rα gene humanized comprising the ATG initiation codon of exon coding 1 to exon coding 5 of the human IL-4Rα gene, and exons coding 6-9 of the rodent IL-4Rα gene, wherein the genomic fragment of the IL gene Rodent -4Rα comprises the ATG initiation codon of exon coding 1 to exon coding 5 of the rodent IL-4Rα gene, and the genomic fragment of the human IL-4Rα gene comprises the ATG initiation codon of exon coding 1 to the exon coding 5 of the human IL-4Rα gene, and wherein the expression of the humanized IL4-Rα gene is under the control of rodent IL-4Rα regulatory elements in the rodent IL-4Rα endogenous locus. |
| priorityDate |
2014-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |