| abstract |
A compound having the structure: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein X is N or CR, where R is hydrogen, deuterium, C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl , aryl, heteroaryl, aryl (C1-C6 alkyl), CN, amino, alkylamino, dialkylamino, CF3 or hydroxyl; A is selected from the group consisting of a bond, C> = O, --SO2--, - (C> = O) NR0-- and - (CRaRb) q--, where R0 is H or C1 alkyl -C4, and Ra and Rb are independently hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl (C1-C6 alkyl), heteroaryl, (C1-C6 alkyl) heteroaryl, heteroaryl (C1-C6 alkyl) and (C1-C6 alkyl) heterocyclic; A 'is selected from the group consisting of a link, C> = O, --SO2--, - (C> = O) NR0', --NR0 '(C> = O) - and - (CRa'Rb ') q--, where R0' is H or C1-C4 alkyl, and Ra 'and Rb' are independently hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl (C1- alkyl) C6), heteroaryl, (C1-C6 alkyl) heteroaryl, heteroaryl (C1-C6 alkyl) and (C1-C6 alkyl) heterocyclic; Z is - (CH2) h-- or a bond, where one or more of the methylene units are optionally substituted with one or more C1-C3 alkyl, CN, OH, methoxy or halo, and where said alkyl may be substituted with one or more fluorine atoms; R1 and R1 'are independently selected from the group consisting of hydrogen, deuterium, C1-C4 alkyl, C3-C6 cycloalkyl, aryl, heteroaryl, aryl (C1-C6 alkyl), CN, amino, alkylamino, dialkylamino, alkoxy, heteroaryl (C1-C6 alkyl) and heterocyclic (C1-C6 alkyl), wherein said alkyl, aryl, cycloalkyl, heterocyclic or heteroaryl is optionally further substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, halo , CN, hydroxy, methoxy, amino, C1-C4-alkyl, di (C1-C4 alkyl) amino, CF3, -SO2 (C1-C6 alkyl) and C3-C6 cycloalkyl; R2 is selected from the group consisting of hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, halo and cyano, wherein said alkyl may be substituted with one or more fluorine atoms; R3 is selected from the group consisting of hydrogen, deuterium and amino; R4 is monocyclic or bicyclic aryl or monocyclic or bicyclic heteroaryl, wherein said aryl or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, heterocycloalkyl, halo, CN, hydroxy, --CO2H , C1-C6 alkoxy, amino, -N (C1-C6 alkyl) (CO) (C1-C6 alkyl), - NH (CO) (C1-C6 alkyl), - (CO) NH2, - (CO ) NH (C1-C6 alkyl), - (CO) N (C1-C6 alkyl) 2, - (C1-C6 alkyl) amino, - N (C1-C6 alkyl) 2, -SO2- (C1 alkyl -C6), - (SO) NH2 and C3-C6 cycloalkyl, wherein said alkyl, cycloalkyl, alkoxy or heterocycloalkyl may be substituted with one or more C1-C6 alkyl, halo, CN, OH, alkoxy, amino, --CO2H , - (CO) NH2, - (CO) NH (C1-C6 alkyl) or - (CO) N (C1-C6 alkyl) 2 and wherein said alkyl may be substituted with one or more fluorine atoms; R5 is independently selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 alkoxy and hydroxyl; h is 1, 2 or 3; j and k are independently 0, 1, 2 or 3; m and n are independently 0, 1 or 2; and, q is 0, 1 or 2. |