http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2655855-T3
Outgoing Links
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|---|---|
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 |
| filingDate | 2014-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d61a4fd32f7f3983a484b79265c6e03b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e965764e8d358faee52a72f963c3cb2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_661e8c882034c8dccfb71ff4bbe08018 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f5a317e531749a09bf279bc75792e98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b29a24b29784da0ee29ecb724ef87a4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e06520aa8cca637385c1ace89721ff8d |
| publicationDate | 2018-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2655855-T3 |
| titleOfInvention | Piperidinyl-indole derivatives and their use as complement factor B inhibitors |
| abstract | A compound, or a salt or tautomer thereof, according to formula (I): ** Formula ** (I) wherein: n is 0, 1 or 2; R is hydrogen, alkyl of 1 to 4 carbon atoms, or hydroxy-alkyl of 1 to 4 carbon atoms; R1 is halogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo-alkyl of 1 to 6 atoms carbon, hydroxy-alkyl of 1 to 6 carbon atoms, amino-alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms-alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 atoms of carbon-alkoxy of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms-alkoxy of 1 to 6 carbon atoms, halo-alkoxy of 1 to 6 carbon atoms, -S (O) box of 1 to 6 carbon atoms, -CH2NHC (O) -alkyl of 1 to 4 carbon atoms or -OCH2C (O) R7, p is 0, 1 or 2; R2 is alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxy-alkyl of 1 to 6 carbon atoms or halogen; R3 is hydrogen, halogen, cyano, alkyl of 1 to 4 carbon atoms, halo-alkyl of 1 to 4 carbon atoms, - CH2C (O) R7, 5 or 6 membered phenyl or heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S, wherein the phenyl or heteroaryl is optionally substituted with 0, 1 or 2 alkyl groups of 1 to 4 carbon atoms, and wherein the alkyl and halo-alkyl they are optionally substituted with 0 or 1 hydroxyl; R4 is phenyl, naphthyl or heteroaryl, wherein the heteroaryl is a five or six membered heteroaryl having 1, 2 or 3 ring heteroatoms independently selected from N, O or S, and wherein the phenyl or heteroaryl is optionally substituted by R5 and is further substituted by 0 or 1 substituent selected from halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, hydroxy-alkyl of 1 to 4 carbon atoms, hydroxyl, and cyano-methyl; R5 is -C (O) R8, -CH2C (O) R8, R9, -C (O) NHSO2 alkyl of 1 to 4 carbon atoms, -SO2NHC (O) -alkyl of 1 to 4 carbon atoms, -SO2N ( H) m (alkyl of 1 to 4 carbon atoms) 2-m, -SO2-alkyl of 1 to 4 carbon atoms, cyano, halogen, hydroxy-alkyl of 1 to 4 carbon atoms and 5-membered heteroaryl having 1 to 4 nitrogen atoms in the ring and 0 or 1 sulfur or oxygen atom in the ring; m is 0, 1 or 2; 30 W is O or C (R6) 2; R6 is independently selected in each presentation from the group consisting of hydrogen, hydroxyl, amino, mono- and di-alkyl of 1 to 4 carbon-amino atoms, alkyl of 1 to 4 carbon atoms, hydroxy-alkyl of 1 at 4 carbon atoms, cyano-alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms; or C (R6) 2, taken in combination, form a spirocyclic carbocycle having 3 to 6 ring atoms; R7 is hydroxy, alkoxy of 1 to 4 carbon atoms, amino, or mono- and di-alkyl of 1 to 4 carbon-amino atoms; R8 is hydroxyl, alkoxy of 1 to 4 carbon atoms, amino, or a saturated heterocycle of 5 to 7 members having 1, 2, or 3 ring heteroatoms independently selected from N, O or S; or R8 is mono- and di-alkyl of 1 to 4 carbon-amino atoms that is unsubstituted or substituted with halogen, hydroxyl, or alkyl of 1 to 4 carbon atoms; and R9 is a heteroaryl of members having 1 to 4 nitrogen atoms in the ring and 0 or 1 oxygen or sulfur atom in the ring, whose heterocycle is optionally substituted by 0 to 2 alkyl groups of 1 to 4 atoms of carbon. |
| priorityDate | 2013-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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