http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2655816-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9008466a40998f8be8e54cd3aceb10a2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-89 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 |
| filingDate | 2008-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_912a91c1e72fa1025d6b677115fd79e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50755a6e51c098904ecfd7c7aa5c278f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7d1b11d42f8871cc20416d6ecb12eeb |
| publicationDate | 2018-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2655816-T3 |
| titleOfInvention | Derivatives of 1-phenyl-2-pyridinyl-alkyl alcohols as phosphodiesterase inhibitors |
| abstract | An inhalable powder formulation comprising a compound of general formula (II) ** Formula ** wherein: Z is selected from the group consisting of (CH2) m where m> = 0, 1 or 2; and CR4R5 wherein R4 is independently selected from H or a linear or branched alkyl (from 1 to 4 carbon atoms) optionally substituted by one or more halogen atoms or by a cycloalkyl (from 1 to 4 carbon atoms), and R5 it is independently selected from the group consisting of straight or branched alkyl (from 1 to 4 carbon atoms), optionally substituted by one or more halogen atoms; - phenyl; - benzyl; - NH2; and - HNCOOR ', wherein R' is linear or branched alkyl (from 1 to 4 carbon atoms) optionally substituted by one or more halogen atoms. R1 and R2 are different or equal and are independently selected from the group consisting of - H; - linear or branched (from 1 to 6 carbon atoms) alkyl, optionally substituted by one or more substituents selected from halogen, cycloalkyl (from 3 to 7 carbon atoms) or cycloalkenyl (from 5 to 7 carbon atoms); - cycloalkyl (from 3 to 7 carbon atoms); - cycloalkenyl (from 5 to 7 carbon atoms); - linear or branched alkenyl (2 to 6 carbon atoms); and - linear or branched alkynyl (2 to 6 carbon atoms). A is a phenyl optionally substituted by one or more Rx groups, or A is a heteroaryl ring optionally substituted by one or more Rx groups, wherein A is a heteroaryl ring selected from the group consisting of pyrrole, pyrazole, furan, thiophene, imidazole , oxazol, isoxazol, thiazole, pyridine, pyrimidine, pyrazine, pyridazine and pyran, in which the optional substituent Rx in the ring A system may be one or more, may be the same or different, and is independently selected from the group that it consists of: - linear or branched alkyl (1 to 6 carbon atoms), optionally substituted by one or more halogen or cycloalkyl atoms (3 to 7 carbon atoms); - linear or branched alkenyl (2 to 6 carbon atoms), optionally substituted by one or more cycloalkyl (3 to 7 carbon atoms); - linear or branched alkynyl (2 to 6 carbon atoms), optionally substituted by one or more cycloalkyl (3 to 7 carbon atoms); - cycloalkenyl (from 5 to 7 carbon atoms); - phenyl; - heterocycloalkyl (from 3 to 7 carbon atoms); - OR7 where R7 is selected from the group consisting of - H; - alkyl (from 1 to 10 carbon atoms) optionally substituted by one or more halogen or cycloalkyl atoms (from 3 to 7 carbon atoms); - cycloalkyl (from 3 to 7 carbon atoms); - alkylene (from 1 to 4 carbon atoms) - heterocycloalkyl (from 3 to 7 carbon atoms); - CO-alkyl (from 1 to 6 carbon atoms), wherein the alkyl (from 1 to 6 carbon atoms) is optionally substituted by one or more halogen atoms; - COO-alkyl (from 1 to 6 carbon atoms), wherein the alkyl (from 1 to 6 carbon atoms) is optionally substituted by one or more halogen atoms; - phenyl; - benzyl; - alkyl (1 to 10 carbon atoms) -NR8R9 wherein R8 and R9 are independently selected from the group consisting of H, linear or branched alkyl (1 to 6 carbon atoms) optionally substituted by one or more halogen atoms and form with the nitrogen atom to which a saturated, partially saturated or unsaturated ring, and halogen atoms are attached; - CN; - NO2; - NR10R11 where R10 and R11 are different or equal and are independently selected from the group consisting of - H; - linear or branched (from 1 to 6 carbon atoms) alkyl, optionally substituted by one or more halogen, phenyl or cycloalkyl atoms (from 3 to 7 carbon atoms); - COC6H5; - CO-alkyl (from 1 to 4 carbon atoms) wherein the alkyl (from 1 to 4 carbon atoms) is optionally substituted by one or more halogen atoms; - COO-alkyl (from 1 to 4 carbon atoms) wherein the alkyl (from 1 to 4 carbon atoms) is optionally substituted by one or more halogen atoms; - CONH-alkyl (from 1 to 6 carbon atoms) -R12, wherein R12 is selected from the group consisting of - H; - alkyl (1 to 4 carbon atoms) optionally substituted by one or more halogen atoms; - OR4R5; and - CONH-alkyl (from 1 to 4 carbon atoms) -N-alkyl (from 1 to 4 carbon atoms) wherein the N-alkyl (from 1 to 4 carbon atoms) is optionally substituted by one or more atoms halogen; or form with the nitrogen atom to which a saturated or partially saturated ring is attached; - alkyl (from 1 to 4 carbon atoms) -NR10R11; - COR12, wherein R12 is linear or branched phenyl or alkyl (from 1 to 6 carbon atoms) optionally substituted by one or more halogen atoms; - oxo; - HNSO2R13 wherein R13 is alkyl (from 1 to 4 carbon atoms) or a phenyl optionally substituted by halogen atoms or a phenyl optionally substituted by halogen atoms or with an optionally substituted alkyl group (from 1 to 4 carbon atoms) by one or more halogen atoms; - SO2R14 wherein R14 is alkyl (from 1 to 4 carbon atoms) optionally substituted by one or more halogen atoms, OH or NR10R11 wherein R10 and R11 are as defined as above; - SOR15, wherein R15 is phenyl or alkyl (from 1 to 4 carbon atoms) optionally substituted by one or more halogen atoms; - SR16 wherein R16 is H, phenyl or alkyl (from 1 to 4 carbon atoms) optionally substituted by one or more halogen atoms; - COOR17, wherein R17 is H, alkyl (from 1 to 4 carbon atoms) optionally substituted by one or more halogen, phenyl or benzyl atoms; and - (CH2) qOR18, where q> = 1, 2, 3 or 4 and R18 is H or cycloalkyl (from 1 to 4 carbon atoms). and pharmaceutically acceptable salts and N-oxides in the pyridine ring thereof. |
| priorityDate | 2007-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 246.