http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2655090-T3
Outgoing Links
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-82 |
| filingDate | 2011-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d440b7ef1a1230ad88c409dcff25740 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e95ac7ca659397c693fd3b6a4a7978fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c348d30de315c63d7ebbe38cc0a4815 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22cbce8c477f3d5802189fcb11ba68d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_556748843d26b1f6693353a0f9e8d7a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1d400e15e05791d34bcdd93c8df31d8 |
| publicationDate | 2018-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2655090-T3 |
| titleOfInvention | 1,2-bis-sulfonamide derivatives as chemokine receptor modulators |
| abstract | A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystalline forms and individual isomers, tautomers or a pharmaceutically acceptable salt thereof, ** Formula ** wherein R1 is H; R2 is H; R3 is C-R7; R4 is C-R8; R5 is 2-thienyl, phenyl, phenyl-4-acetamide, 4-chloro-3-trifluoromethylphenyl, -1-methyl-1H-imidazole, 3-pyridine, 2 aminophenyl, 1,3-dimethyl-1H-pyrazole, 1- methyl-1H-pyrazole, 1-methyl-1H-imidazole, 4- (1H-pyrazol-1-yl) phenyl, 1,3-thiazol-4-yl) phenyl, 4- (1,3-oxazol-5- yl) phenyl, 2- (methylamino) benzoate, 1-methyl-1H-indole, 2-oxoindoline, 1-methyl-2,3-dioxoindoline, 1-methyl-2-oxoindoline, 2-furan, 4-biphenyl, 3 , 5-difluorophenyl, 3,5-dichlorophenyl, -3,5-dimethylisoxazole, 4-chloro-2,5-difluorophenyl, 4- (2-methylphenoxy) phenyl, 5-isoxazol-3-ylthiophene, 2,6-dichlorophenyl , 4- (methylsulfonyl) phenyl, 3,4-difluorophenyl, 4-chloro-3- methylphenyl, 2-oxo-2,3-dihydro-1,3-benzoxazole, 4-benzoic acid, 2-methoxybenzoic acid, 3- cyanophenyl, 4-tert-butylphenyl, 1,3-benzothiazole, 1H-1,2,4-triazole, 2-chloro-1,3-benzothiazole, 2,4-dimethoxyphenyl, 2,5-dichloro-3-thienyl, 3- methoxyphenyl, 3- (methylsulfonyl) phenyl, 3-chloro-2-methylphenyl, 4phenylpropanoic acid, 2-ethoxybenzoic acid, 2-methylphenyl} acetamide, 3,5-bis (trifluoromet yl) phenyl, 1H-pyrazole, 4- (trifluoromethoxy) phenyl, 4- (benzyloxy) phenyl, 2-chloro-4-fluorobenzoic acid, thiophene-2-carboxylate, 4-fluorobenzoic acid, 2-chloro-quinoline, 2, 3-dihydro-1H-indene, 1-naphthyl, 1,3-benzodioxol, 3,5-dichloro-2-hydroxyphenyl, 2-benzofuran, quinoline, 4-methylbenzoate, 2,4-dimethyl-1,3-thiazole, 4-methyl-1,3-thiazol-2-yl} acetamide, 5-chloro-8-quinoline, 2,4,5-trifluorophenyl, 3,4-dimethoxyphenyl, 3,5-dimethyl-1H-pyrazole, 1- (phenylsulfonyl) -1H-pyrrole, N-acetylindoline, 1,3,4-oxadiazol-2-yl-phenyl, 3- (1-methyl-1H-pyrazol-3-yl) phenyl, 2-thienylsulfonyl) amino] phenyl -4-methyl, 2-oxo-2H-chromene, 6-phenyl-3-pyridine, 2-chloro-4- (trifluoromethyl) phenyl, 6-phenoxypyridine, 5-phenylthiophene, 2,5-dimethyl-3-thienyl, 2-chlorophenyl-4-acetamide, (5-chloro-2,4-difluorophenyl, 4- (1-methyl-1H-pyrazol-3-yl) phenyl, 5-methyl-1-benzothiophene, 2,5-dimethylfuran, 4- (pyrrolidin-1-ylsulfonyl) phenyl, methyl-2-methyl-3-furoate, 3-oxo-3,4-dihydro-2H-1,4-benzoxazine, 2,4-dichloro-benzoic acid, 5- {[(dimethylam ino) carbonyl] amino} -2-ethoxyphenyl, 2- methoxyphenyl} acetamide, 2- imidazo [2,1-b] [1,3] thiazole, 6-morpholin-4-ylpyridine, 3 - [(6-methylpyrazin- 2-yl) oxy] phenyl, 5-pyridin-2-ylthiophene, 3-pyrimidin-2-ylphenyl, 4-dihydro-2H-pyrido [3,2-b] [1,4] oxazine, 6- (dimethylamino) -2-naphthyl, 2- (methylsulfonyl) phenyl, 3-methyl-8-quinoline, 5-isoxazol-5-ylthiophene, 5- (dimethylamino) -1-naphthyl, 2-chloro-thienyl, methyl, ethyl, benzyl, iso-butyl, 2,2-dimethylchroman, 2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine, 4-methyl-3,4-dihydro-2H-1,4-benzoxazine, 4- acetyl-3,4-dihydro-2H-1,4-benzoxazine, 4- (benzyloxy) phenyl, 2,4-dimethyl-1,3-thiazole, 3,5-dimethylisoxazole, 5-chloro-3-methyl-1 -benzotien- 2-yl, 2-chloro-4-fluorobenzoic acid, 4-methyl-1,3-thiazol-2-yl} acetamide, 1H-1,2,4-triazole, phenylpropanoic acid, 5-chlorothiophene-2 -carboxylate, 3-phenylacetamide, 2-oxoindoline, 2-oxo-2,3-dihydro-1,3-benzoxazole, 5-isoxazol-3-yl-2-thienyl, 2-chloroquinoline, 1- (phenylsulfonyl) -1H -pyrrole, 2,5-dichloro-3-thienyl, 5 - {[(dimethylamino) carbonyl] am ino} -2-ethoxyphenyl, 6-morpholin-4-ylpyridine, 4-methoxythiophene, 3-furyl, 1-methyl-1H-pyrazole, 6-chloroimidazo [2,1-b] [1,3] thiazole, 3- (5-methyl-1,2,4-oxadiazol-3-yl) phenyl, 3-pyrimidin-2-ylphenyl, 1-acetyl-indoline, isonicotinate, 3- (5-methyl-1,3,4-oxadiazole- 2- yl) phenyl, 4- (3,5-dimethyl-1H-pyrazol-1-yl) phenyl, 3,5-dimethyl-1-phenyl-1H-pyrazole, 4-methyl-3,4-dihydro-2H -1,4-benzoxazine, 3,4-dihydro-2H-1,5-benzodioxepin, 2,2-dimethylchroman, 4-methyl-2-phenyl-1,3-thiazole, 5-pyridin-2-yl-2 -thienyl, 4-methyl-3,4-dihydro-2H-pyrido [3,2-b] [1,4] oxazine, 3-oxo-3,4-dihydro-2H-1,4-benzoxazine, 5, 6-dichloro-3-pyridine, 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline, or 4-acetyl-3,4-dihydro-2H-1,4-benzoxazine; R6 is 2-benzofuran, 2-thienyl, 5-chloro-2-thienyl, 4,5-dichloro-2-thienyl, 4-chloro-3-methylphenyl, or 4-chloro-3-trifluoromethylphenyl; R15 is C-R16; R17 is N or C-R18; R7 is H, methyl or chlorine; R8 is H or chlorine; R16 is H, and R18 is H with the condition; to). R6 is not the same as R5; b). when R5 is a substituted heterocycle then it is not ** Formula ** c). when R6 is 2-thienyl then R7, R8, R16 and R18 are not all hydrogens at the same time; d). the compound is not of the following structures: ** Formula ** |
| priorityDate | 2010-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 205.