| abstract |
A compound of Structural Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, in which: X is -CF3; Y is selected from hydrogen, -alkylene (C1-C4) -N (R2) (R3), -CH> = N-OR2, -C (O) -N (R2) (R4), -NO2, -COOH, -OH, - N> = CH-N (R2) (R3), -N (R2) (R3), -N (RF) -C (O) - [C (R5a) (R5b)] 1-4- N (R2) (R3), -N (RF) -C (O) -alkyl (C1-C6), -N (RF) -C (O) - heterocyclyl, -N (RF) -C (O) - carbocyclyl, -N (RF) -S (O) m-alkylene (C1-C4) -N (R2) (R3), -N (RF) -S (O) mN (R2) (R4) and - N ( RF) -S (O) m-alkylene (C1-C4) -carbocyclyl, wherein: each R2 is independently selected from hydrogen and (C1-C3) alkyl; each R3 is independently selected from hydrogen, (C1-C6) alkyl, -O-(C1-C6) alkyl, -alkylene (C0-C6) -carbocyclyl, -alkylene (C0-C6) -heterocyclyl, -S (O) m-(C1-C6) alkyl, -S (O) m-carbocyclyl and -S (O) m-heterocyclyl; and each R4 is independently selected from hydrogen, (C1-C6) alkyl, -O-(C1-C6) alkyl, -alkylene (C0-C6) -carbocyclyl and -alkylene (C0-C6) -heterocyclyl; or R2 and R3, taken together with the nitrogen atom to which they are attached form a heterocyclyl, wherein the heterocyclyl optionally comprises 1 to 4 additional heteroatoms independently selected from N, S and O; each R5a and each R5b are independently selected from hydrogen, (C1-C6) alkyl, carbocyclyl, heterocyclyl or a naturally occurring amino acid side chain residue, or R5a and R5b taken together with the carbon atom to which they are attached form a 3-7 membered saturated carbocyclyl or a 4-7 membered saturated heterocyclyl, wherein the saturated heterocyclyl formed by R5a and R5b optionally comprises one or two additional heteroatoms independently selected from N, S and O, RF is hydrogen or (C1) alkyl -C3); each m is 1 or 2, where: each carbocyclyl or heterocyclyl is optionally and independently substituted with one or more substituents independently selected from chlorine, fluorine, (C1-C4) alkyl, -OH, -O, (C1-C4) alkyl , (C1-C4) alkyl substituted with fluorine, -C (O) -alkyl (C1-C4), -C (O) - (fluorinated (C1-C4) alkyl) and -N (RG) (RG) ; each RG is hydrogen or (C1-C4) alkyl, wherein each alkyl in the group represented by RG is optionally and independently substituted with one or more substituents independently selected from - (C1-C4) alkyl, (C3-C6) cycloalkyl, halo, -OH, -O-C1-C4 alkyl and -C1-C4 alkyl-O-C1-C4 alkyl; and each alkyl is optionally and independently substituted with one or more substituents independently selected from fluorine, chlorine, -O-(C1-C4) alkyl and (C1-C4) alkyl substituted with fluorine. |