| abstract |
An implant (100) suitable for implantation in a mammal for the treatment, repair or replacement of defects or a lesion in musculoskeletal tissue, comprising: a solid hydrogel (110); a porous hydrogel (120) adjacent to the solid hydrogel (110); and a rigid porous base (130); characterized in that the solid hydrogel (110) and the rigid porous base (130) carry the articular load, and the porous hydrogel layer (120) and the rigid porous base (130) allow cell migration to the interior and around the implant (100 ) and the solid hydrogel (110) is attached to or integrated with the rigid porous base (130) by mechanical immobilization or entanglement and where before implantation, the implant (100) is dehydrated so that the solid hydrogel (110) and the porous hydrogel (120) decrease in size and / or change shape and, after implantation, the implant (100) is rehydrated and the solid hydrogel (110) and the porous hydrogel (120) increase in size and / or recover their forms and, where the porous hydrogel (120) is rehydrated before the solid hydrogel (110). |