| abstract |
An isolated polypeptide consisting of no more than 15 amino acid residues and said polypeptide comprising the WEHVNAIQEARRLL amino acid sequence (SEQ ID NO: 35), wherein said polypeptide has cellular protective activity. wherein the cellular protective activity is determined in vivo in an animal model of protection against sciatic nerve injury, or in which the cellular protective activity comprises neuroprotection, which is determined in vitro by a method comprising the steps of: (a ) contacting a test culture of primary hippocampal neurons with N-methyl-D-aspartate and said peptide; and (b) determine the cell viability at 48 hours after said contact, so that if the cell viability determined in step (b) is greater than that of a control culture in the absence of said peptide, the peptide possesses protective activity mobile. |