abstract |
A therapeutic composition, comprising an isolated aminoacyl-tRNA synthetase (AARS) polypeptide consisting of an amino acid sequence that is at least 90%, 95%, 98% or 100% identical to SEQ ID NO: 34, in which the polypeptide has an extracellular signaling activity and has a solubility of at least about 5 mg / ml, and wherein the composition has a purity of at least about 95% in proteins and less than about 10 EU of endotoxin / mg of protein |