http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2653559-T3
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-30 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-22 |
filingDate | 2014-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2018-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_839ca7b32c058699fe23dd49c37dfc48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17e9db18f7b9d66ab05061d1fbff02ba |
publicationDate | 2018-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2653559-T3 |
titleOfInvention | Procedure for the preparation of a chiral 2- (4-aminophenyl) morpholine |
abstract | Process for the preparation of a chiral 2- (4-aminophenyl) morpholine of formula ** Formula ** in which R 1 is hydrogen or represents a protective group of amino PG, comprising steps a) an enzymatic reduction of a ketone of formula ** Formula ** in which X is a halogen atom with an oxidoreductase to form the chiral alcohol of formula ** Formula ** b) the formation of the N-protected ethanolamine compound of formula ** Formula ** in the that PG is an amino protecting group; c) cyclization of the N-protected ethanolamine compound of formula IVa to form 2- (4-nitrophenyl) morpholine of formula ** Formula ** in which PG is as defined above; by reacting the N-protected ethanolamine compound of formula IVa with a sulfonyl halide of formula ** Formula ** in which R 3 is C 1-4 alkyl or phenyl optionally substituted with a C 1-4 alkyl group, a nitro group or a halogen atom and X is as defined above, to form an intermediate sulphonate of formula ** Formula ** in which PG and R3 are as above and by subsequent direct cyclization with a non-nucleophilic base; and d) the reduction of the nitro group to form the chiral 2- (4-aminophenyl) morpholine of formula I and e) the optional removal of the amino PG protecting group. |
priorityDate | 2013-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 403.