http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-265331-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d037bc74e34c7d73dd883f208aef0518 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-397 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1961-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-265331-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF TRIMETOXY-BENZAMINES |
| abstract | The invention comprises compounds of the formula <FORM:0897989/IV (b)/1> (wherein R and R1 are alkyl radicals each containing at most 8 carbon atoms) and their preparation by heating p-hydroxy-benzylamine with 3,4,5-trimethoxybenzoyl chloride in an inert anhydrous organic solvent in the presence of a tertiary amine, heating an alkali metal salt of the precipitated N-(p-hydroxybenzyl)-3,4,5-trimethoxybenzamide at 65 DEG C. to 70 DEG C. with an N-chloroethyl-3,3-dialkyl-azetidine in an inert anhydrous organic solvent, evaporating the mixture to dryness, taking up the residue in an organic solvent, evaporating after filtration of the inorganic salt, taking up the residue with diethyl ether and precipitating the product by adding light petroleum. An example is given. N - Chloroethyl - 3, 3 - dialkylazetidines are prepared by reacting 3,3-dialkylazetidines with ethylene oxide to give 3,3-dialkyl-1-(b -hydroxyethyl)-azetidines and reacting these with thionyl chloride. The compounds of the invention, which are stated to be antihistaminic and antiemetic agents, may be formulated as pharmaceutical compositions with solid or liquid carriers or diluents. |
| priorityDate | 1960-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.