| abstract |
Compound or physiologically acceptable salt thereof, which has the formula: ** Formula ** in which R1> = ** Formula ** or in which n> = 0-2, and when n> = 2, each occurrence of R8 is independently selected; R2> = - [C (> = O) NH (CH2) nNHC (> = O)] m (L) mZ, where n> = 0-30, m> = 0-1, L is a group of union and Z is a benzyl aminosulfonic acid, a benzyl aminocarboxylic acid, or a polyethylene glycol; R310> = ** Formula ** -OC (> = O) -X, -NH2, -NH-C (> = O) -NHX or -NH-C (> = O) -X where n> = 0-2 and X are independently selected from C1-C8 alkanyl, C2-C8 alkenyl, C2-C8 alkynyl, ** Formula ** and in which n> = 0-10, and any of the above ring compounds may be substituted with one to three substituents independently selected from Cl, F, C1-C8 alkynyl, C2-C8 alkenyl, C2-C8 alkynyl, C6-C14 aryl, or OY wherein Y is independently selected from H, C1-C8 alkanyl , C2-C8 alkenyl, C2-C8 alkynyl or C6-C14 aryl; R4> = ** Formula ** 6 'sulfated GlcNAc, 6' carboxylated GlcNAc, 6 'sulfated GalNAc, 6' sulfated galactose, 6 'carboxylated galactose or ** Formula ** in which R9 is aryl, heteroaryl, cyclohexane, t -butane, adamantane or triazole, and any of R9 may be substituted with one to three substituents independently selected from Cl, F, C1-C8 alkynyl, C2-C8 alkenyl, C2-C8 alkynyl and OY in which Y is H, C1-C8 alkanyl, C2-C8 alkenyl, C2-C8 alkynyl or C6-C14 aryl; ** Formula ** R5> = H, or R4 and R5 are taken together to form ** Formula ** in which R10 is aryl , 5 heteroaryl, ** Formula ** in which n> = 0-10, and any one of the above ring compounds may be substituted with one to three substituents independently selected from Cl, F, C1-C8 alkanyl, alkenyl C2-C8, C2-C8 alkynyl and OY in which Y is H, C1-C8 alkynyl, C2-C8 alkenyl, C2-C8 alkynyl; ** Formula ** R6> = H, fucose, mannose, arabinose, galactose or polyol; R7> = H, C1-C8 alkynyl, C2-C8 alkenyl, C2-C8 alkynyl or ** Formula ** R8> = H, C1-C8 alkynyl, C2-C8 alkenyl, C2-C8 alkynyl, ** Formula ** where n> = 0-3 and X is independently selected from H, OH, Cl, F, N3, NH2, C1-C8 alkynyl, C2-C8 alkenyl, C2-C8 alkynyl, C6-C14 aryl, O-alkanyl C1-C8, O-C2-C8 alkenyl, O-C2-C8 alkynyl and O-aryl C6-C14, and any of the above ring compounds may be substituted with one to three substituents independently selected from Cl, F, alkanyl C1-C8, C2-C8 alkenyl, C2-C8 alkynyl, C6-C14 aryl and OY in which Y is H, C1-C8 alkynyl, C2-C8 alkenyl, C2-C8 alkynyl or C6-C14 aryl. |