| abstract |
A conjugate comprising a target binding moiety linked through an L-linker to an amatoxin, wherein the L-linker is connected to the amatoxin by means of (i) the ΥC atom of the amino acid 1 of the amatoxin, in particular by means of an amide bond; (ii) an oxygen atom attached to the δ C atom of amino acid 3 of amatoxin, in particular by means of an ester bond, an ether bond or a urethane bond; or (iii) the 6'C atom of amino acid 4 of amatoxin, in particular by means of an oxygen atom attached to the 6'C atom of amino acid 4 of amatoxin; in each case where the connector L is connected to the rest of the target junction by means of a urea moiety. |