http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2651514-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da6012a6809db78e155927b5ba9b955d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-312 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-316 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-351 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-34 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-712 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate | 2012-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74c3f62705ec8baff74a32c28dfacf3a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e642c2662e9d13a3bf03b7e77372ba57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e3bc6e38e6d5720bf0264f54131f22f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1edad75d831e35cde2739d225a3f1f0 |
| publicationDate | 2018-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2651514-T3 |
| titleOfInvention | Gauged oligomeric compounds comprising 5'-modified deoxyribonucleosides - in the gap and uses thereof |
| abstract | An oligomeric compound with gaps comprising a contiguous sequence of joined monomeric subunits having an interstitial region located between a 5 'region and a 3' region in which regions 5 'and 3' each independently have 2 to 8 RNA-like contiguous nucleosides that are modified furanosyl nucleosides that adopt a 3'-endo shaped geometry when placed in an oligomeric compound and the hollow region has 6 to 14 contiguous monomer subunits selected from ß-D- 2'- 5'-substituted deoxyribonucleosides and 5'-substituted β-D-2'-deoxyribonucleosides having Formula I: ** Formula ** where independently for each 5'-substituted β-D-2'-deoxyribonucleoside having Formula I : T1 and T2 are each, independently, an internucleoside binding group that binds the 5'-substituted β-D-2'-deoxyribonucleoside having Formula I with the remainder of the separated oligomeric compound; Bx is a heterocyclic base moiety; R1 is C1-C6 alkyl, substituted C1-C6 alkyl, C2-C6 alkenyl, substituted C2-C6 alkenyl, C2-C6 alkynyl or substituted C2-C6 alkynyl; Each substituted group comprises one or more optionally protected substituent groups independently selected from halogen, OJ1, NJ1J2,> = NJ1, SJ1, N3, CN, OC (> = L) J1, OC (> = L) NJ1J2 and NJ3C (> = L ) NJ1J2, wherein each J1, J2 and J3 is, independently, H, C1-C6 alkyl or a protecting group, and L is O, S or NJ1; and wherein said interstitium region comprises at least one 5'-substituted β-D-2'-deoxyribonucleoside having Formula I and a plurality of β-D-2'-deoxyribonucleosides; said separate oligomeric compound having a 5'-substituted β-D-2'-deoxyribonucleoside of Formula I, or having two 5'-substituted β-D-2'-deoxyribonucleosides of Formula I, or having three β-D -2'- 5-substituted deoxyribonucleosides of Formula I. |
| priorityDate | 2011-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.