abstract |
A fully occupied IL-15N72D: IL-15RαSu / Fc complex comprising a dimer comprising two interleukin-15 receptor fusion polypeptides (IL-15), wherein each IL-15 receptor fusion polypeptide comprises a domain of IL-15 sushi binding fused to an Fc domain (IL-15RαSu / Fc), and two variant IL-15 polypeptides comprising an N72D mutation (IL-15N72D polypeptides), wherein each sushi binding domain of IL-15 is linked to an IL-15N72D polypeptide, where optionally IL-15N72D and / or the IL-15RαSu / Fc fusion protein is glycosylated. |