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publicationDate 2018-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2651028-T3
titleOfInvention Process to produce and purify factor VIII and its derivatives
abstract The use of dextran sulfate to reduce or block the activities that cleave Factor VIII of certain or certain proteases from culture media of CHO cells and to increase the homogeneity of Factor VIII molecules produced in a process for the production of Factor VIII in CHO cells adapted to a serum-free medium that is supplemented with dextran sulfate, where the average molecular weight of said dextran sulfate is 20 to 5000 kDa.
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