| abstract |
A compound of formula IA: ** Formula ** in which: Y is -C (O) -; X1 is C (R3) 2 and X2 is -O-, and the dotted line is a single link; Q is a covalent bond; R1 is C3-6 cycloalkyl, C3-6 cycloalkenyl or aryl; wherein said C3-6 cycloalkyl, C3-6 cycloalkenyl or aryl are substituted with one, two or three substituents independently selected from the group consisting of halogen, -NO2, CN, - SF5, -Si (CH3) 3, -O -R20, -S- R20, -C (O) -R20, -C (O) -OR20, -N (R20) (R22), -C (O) -N (R20) (R22), -N ( R20) -C (O) -R22, -N (R20) -S (O) 2-R22, -S (O) 2-R20, - S (O) 2-N (R20) (R22), alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-6 cycloalkyl, aryl, heteroaryl and heterocyclyl; and wherein said C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-6 cycloalkyl, aryl, heteroaryl or heterocyclyl optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, -NO2 , aryl, heterocyclyl, heteroaryl, C1-4 alkyl, C3-6 cycloalkyl, - N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) -N ( R20) (R22), -CN and -O-R20; R2 is -R6, -C1-6-R6 alkylene, -C2-6-R6 alkylene, -C2-6-R6 alkylene, -L-R6, -L-C1-6-R6 alkylene, -C1-6 alkylene L-R6 or -C1-6-L-C1-6-R6 alkylene; L is -O-, -S-, -C (O) -, -S (O) 2-, -NR20S (O) 2-, -S (O) 2NR20-, -C (O) NR20- or - NR20C (O) -; each R3 is independently hydrogen, C1-6 alkyl, C3-6 cycloalkyl, aryl, heteroaryl or heterocyclyl; wherein said C1-6 alkyl is optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, -NO2, C3-6 cycloalkyl, aryl, heterocyclyl, heteroaryl, -N (R20) (R22), - C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -CN and -O-R20; wherein said C3-6 cycloalkyl, aryl, heterocyclyl and heteroaryl are optionally further substituted with one, two or three substituents independently selected from the group consisting of halogen, -NO2, C1-6 alkyl, aralkyl, C3-6 cycloalkyl, aryl, heterocyclyl, heteroaryl, - N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -CN and -O-R20 ; and wherein said C1-6 alkyl, aralkyl, C3-6 cycloalkyl, aryl, heterocyclyl and heteroaryl are optionally further substituted with one, two or three substituents independently selected from the group consisting of halogen, -NO2, -N (R20) ( R22), -C (O) -R20, -C (O) -OR20, - C (O) -N (R20) (R22), -CN and -O-R20; or two R3 can be linked together with the carbon atom to which they are attached to form a C3-6 cycloalkyl or a heterocyclyl; R6 is C3-6 cycloalkyl, aryl, heteroaryl or heterocyclyl; wherein said C3-6 cycloalkyl, aryl, heteroaryl or heterocyclyl are optionally substituted with one, two or three substituents independently selected from the group consisting of C1-6 alkyl, C2-4 alkynyl, halogen, -NO2, C3-6 cycloalkyl, aryl, heterocyclyl, heteroaryl, -N (R20) (R22), -N (R20) -S (O) 2- R20, -N (R20) -C (O) -R22, -C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -S (O) 2-R20, -CN and -O-R20; wherein said C1-6 alkyl, C3-6 cycloalkyl, aryl, heterocyclyl or heteroaryl are optionally further substituted with one, two or three substituents independently selected from the group consisting of halogen, -NO2, C1-6 alkyl, C3-6 cycloalkyl , aryl, heterocyclyl, heteroaryl, - N (R20) (R22), -C (O) -R20, C (O) -OR20, -C (O) -N (R20) (R22), -CN and -O -R20; and wherein said C1-6 alkyl, C3-6 cycloalkyl, aryl, heterocyclyl or heteroaryl are optionally further substituted with one, two or three substituents independently selected from the group consisting of C1-6 alkyl, halogen, aryl, -NO2, - CF3, -N (R20) (R22), -C (O) -R20, -C (O) - OR20, -C (O) -N (R20) (R22), -CN, -S (O) 2 -R20 and -O-R20; |