http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2648687-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c88d09c0c47c845abf8d53da9ad0592b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-18 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K4-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4748 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 2008-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46ac1216fec292d82ab5f93971e12948 |
| publicationDate | 2018-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2648687-T3 |
| titleOfInvention | Triazole-linked macrocyclic peptides |
| abstract | Peptidomimetic macrocycle comprising an α helix of formula (I): ** Formula ** in which: each A, C, D and E is independently a natural or non-natural amino acid; B is independently a natural or non-natural amino acid, [-NH-L3-CO-], [-NH-L3-SO2-] or [-NH-L3-]; R1 and R2 are independently -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl or heterocycloalkyl, unsubstituted or substituted by halogen, where at least one of R1 and R2 is alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl or heterocycloalkyl, unsubstituted or substituted by halogen; each R3 is independently hydrogen, alkyl, alkenyl, alkynyl, arylalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, cycloaryl or heterocycloaryl, optionally substituted with R5; L is a joining element that forms macrocycles of formula ** Formula ** L1, L2 and L3 are independently alkylene, alkenylene, alkynylene, heteroalkylene, cycloalkylene, heterocycloalkylene, cycloarylene or heterocycloarylene, each being optionally substituted with R5; each R5 is independently halogen, alkyl, -OR6, -N (R6) 2, -SR6, -SOR6, -SO2R6, -CO2R6, a fluorescent moiety, a radioisotope or a therapeutic agent; each R6 is independently -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkylalkyl, heterocycloalkyl, a fluorescent moiety, a radioisotope or a therapeutic agent; R7 is -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, cycloaryl or heterocycloaryl, optionally substituted with R5, or part of a cyclic structure with a residue D; R8 is -H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, cycloaryl or heterocycloaryl, optionally substituted with R5, or part of a cyclic structure with a residue E; v is an integer from 1 to 1000; w is an integer from 1 to 1000; x is an integer from 0 to 10; and is an integer from 0 to 10; and z is an integer from 0 to 10. |
| priorityDate | 2007-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 277.