http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2648614-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7da5c8e8c3e8261efe7e698c7198681b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-77 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-00 |
| filingDate | 2016-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a26452965f4e63c9e03c0c6707bd4550 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63a3130251c8c07e552f917019bf5ea6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec67a2615424348d946bfeb02535607c |
| publicationDate | 2018-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2648614-B1 |
| titleOfInvention | PRODUCTION OF STEROIDS 11-ALFA HYDROXYLATES THROUGH BIOTRANSFORMATION WITH RECOMBINANT BACTERIA |
| abstract | Production of hydroxylated 11 {al} steroids by biotransformation with recombinant bacteria. # The present invention provides a method for producing hydroxylated 11 {al} steroidal compounds or by fermentation of natural sterols or by biotransformation of different steroid syntheses with recombinant bacteria , preferably from Mycobacterium smegmatis or from Corynebacterium glutamicum. Said recombinant bacteria carry a plasmid comprising a synthetic operon containing the cyp509Cl2 and roCPR1 genes of Rhizopus oryzae, which encode cytochrome CYP509C12 with 11 {al} -hydroxylase activity and cytochrome reductase (RoCPR1) necessary for cytochrome activity. By the method described in the present invention, 11 {al} OH-ADD or 11 {al} -OH-AD can be produced, but not limited to, from natural sterols such as cholesterol or phytosterols, or 11 {al} -OH- PROG, 11 {al} -OH-DOC, 11 {al} -OH-TEST, 11 {al} -OH-DHEA, 11 {al} -OH-AD and / or 11 {al} -OH-ADD from of their corresponding non-hydroxylated tunes. |
| priorityDate | 2016-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 313.