http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2648197-T3

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-7061
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filingDate 2009-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2017-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5bacff7b3988042d81d9d8e9a6f4bcf
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publicationDate 2017-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2648197-T3
titleOfInvention Medicated patch
abstract Medicated patch comprising a support and a pressure sensitive adhesive layer provided on the support and having an acid number of no more than 28, in which the pressure sensitive adhesive layer comprises a composition containing, such as medicinal agent, varenicline in its free base form, a metal salt, an adhesive base material and an adsorbent that adsorbs a polar solvent in the composition, in which varenicline in its free base form and the salt of metal by a neutralization reaction between an addition salt of varenicline acid and an alkali metal hydroxide, which is added in an amount to convert all or a portion of the varenicline into the free base form, in which the salt of Acid addition of medicinal agent is selected from hydrochloride, acetic acid salt, sulfuric acid salt, maleic acid salt, oxalic acid salt, citric acid salt, iodhydric acid salt, hydrobromic acid salt, salt of mesilic acid, salt of tartaric acid or salt of succinic acid of the medicinal agent, in which the composition has a pH of 7.5 or greater, the pH being the pH of an aqueous solution obtained by mixing the medicated patch in water for dissolve the water soluble components, and in which the adhesive base material is an acrylic based polymer that does not contain carboxyl groups.
priorityDate 2008-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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