| abstract |
Method for reducing the activity of FXIa in a pharmaceutical preparation of immunoglobulin derived from a plasma fraction, said fraction comprising antithrombin III plasma, the method comprising contacting the plasma fraction with heparin, thus reducing the activity of FXIa by mL of the plasma fraction, where heparin is covalently coupled to a matrix and the plasma fraction has been pre-absorbed into an anion exchange matrix, where the anion exchange matrix is an anion exchange membrane. |