abstract |
Isolated antibody or binding fragment thereof that specifically binds to human B7-H1, wherein the antibody or binding fragment thereof comprises: a VH CDR1 having the amino acid sequence GFTFSRYWMS; and a VH CDR2 having the amino acid sequence NIKQDGSEKYYVDSVKG; and a VH CDR3 having the amino acid sequence EGGWFGELAFDY; and a CDR1 of VL having the amino acid sequence RASQRVSSSYLA; and a VR CDR2 having the amino acid sequence DASSRAT; and a VL CDR3 having the amino acid sequence QQYGSLPWT, and in which the antibody or binding fragment thereof inhibits tumor proliferation induced by B7-H1. |