abstract |
A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof: ** Formula ** wherein: A1 is a group selected from the group consisting of the following a) to c): a) C6-C10 aryl, wherein the anyl is unsubstituted or substituted by 1 to 2 substituents independently selected from the group consisting of the following: a halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1- haloalkoxy atom C6, (C1-C6) alkoxycarbonyl, cyano, C1-C6 hydroxyalkyl, carbamoyl, nitro, amino, (C1-C6) alkoxycarbonylamino-C1-C6alkyl, mono (di) (C1-C6) alkyl, alkyl ( C1-C6) carbonylamino, (C1-C6) alkyl sulfonylamino and (C1-C6) alkyl sulfonyl, b) 5-membered heterocycle, wherein the anyl is unsubstituted or substituted with 1 to 2 substituents selected independently from the group consisting of in the following: a halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, cyano and C1-C6 haloalkoxy atom, and c) 6-membered heterocycle, wherein the anyl is unsubstituted or substituted with 1 to 2 substituents independently selected from the group consisting of the following: a halogen atom, 20 hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, cyano and C1-C6 haloalkoxy; A2 is a group selected from the group consisting of the following d) to f): d) C6-C10 aryl, wherein the anyl is unsubstituted or substituted with 1 to 2 substituents selected independently from the group consisting of the following: a halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 hydroxyalkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, cyano, amino, nitro, carboxy, (C1-C6) alkyl carbonylamino, (C1 -C6) carbonyloxy, (C1-C6) alkylcarbonyl and (C7-C10) aralkyl oxycarbonyl, e) heterocycle, wherein the anyl is unsubstituted or substituted with 1 to 2 substituents selected independently from the group consisting of the following: a halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, cyano, mono (di) (C1-C6) alkyl, amino (C1-C6) alkylsulfanyl, amino atom , (C7-C10) aralkyl oxycarbonyl, C1-C6 hydroxyalkyl, C1-C6 hydroxyalkoxy, C2-C6 alkenyl, morpholino and (C1-C6) alkylcarbonyl, and f) C3-C6 cycloalkyl; X is CH or N; Y is -CR1R2- or an oxygen atom; R1 and R2 independently represent a hydrogen atom, a halogen atom or C1-C6 alkyl; R3 and R4 independently represent a hydrogen atom, a halogen atom, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkoxy, C2-C6 alkenyl or cyano with the proviso that when X is CH, and R1 and R2 are hydrogen atoms, R3 and R4 are not hydrogen atoms at the same time; and n is 1 or 2. |