http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2645638-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 |
| filingDate | 2013-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c9e06a50ada7c10b636a3707f9e8454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c0ef7fe07489825c219b493f1bdca7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ec3dcfd88feacd22de71e8c9338f8f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_064518c396b9542e3746488087df4666 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99823cb0abb76cdec1b791074a0e6ce0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e3005a3a8b3483e70902562a8d0b45b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91536f8c3d16cd2316c0f7ccceae57f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9324e49cdf3850db9d4aa9b23711367 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e4214185f4e01d7dd284fa4763a846a |
| publicationDate | 2017-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2645638-T3 |
| titleOfInvention | 5-Phenoxy-3H-pyrimidin-4-one derivatives and their use as HIV reverse transcriptase inhibitors |
| abstract | A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, in which: M is CH2, CH2CH2, CH2CH2CH2, CH (CH3), C (CH3) 2 or C (O) N (RA) ; Z is selected from the group consisting of: pyridazine, pyridazinone, pyrimidine, pyrimidinone, pyrazine, pyrazinone, triazine and triazinone, each optionally substituted with one or more substituents, up to the maximum number allowed by valence, selected from R4 and R5 ; each R1 is independently selected from the group consisting of: halogen, CN, NO2, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, OH, O-C1-4 alkyl, O-C1-4 haloalkyl, N (RA) RB, C (O) N (RA) RB, C (O) RA, CO2RA, SRA, S (O) RA, SO2RA, SO2N (RA) RB, SO2N (RA) C (O) RB or alkenyl C2-4 substituted with CN; R2 is selected from the group consisting of: (1) H, (2) C1-6 alkyl, (3) C1-6 haloalkyl, (4) C1-6 alkyl substituted with 1 to 3 substituents, each of which is independently OH, C1-6alkyl, C1-6 O-haloalkyl, CN, NO2, N (RA) RB, C (O) N (RA) RB, C (O) RA, CO2RA, SRA, S (O) RA, S (O) 2RA, S (O) 2N (RA) RB, N (RA) C (O) RB, N (RA) CO2RB, N (RA) S (O) 2RB, N (RA) S ( O) 2N (RA) RB, OC (O) N (RA) RB, N (RA) C (O) N (RA) RB or N (RA) C (O) C (O) N (RA) RB, (5) O-C1-6 alkyl in which the alkyl is optionally substituted with 1 to 3 substituents independently selected from OH, O-C1-6 alkyl, O-haloalkyl C1-6, CN, N (RA) RB, C (O) N (RA) RB, C (O) RA, CO2RA, SRA, S (O) RA, S (O) 2RA or S (O) 2N (RA) RB, (6) C1-6 O-haloalkyl , (7) halogen, (8) CN, (9) NO2, (10) N (RA) RB, (11) C (O) N (RA) RB, (12) C (O) RA, (13) C (O) -haloalkyl C1-6, (14) C (O) ORA, (15) OC (O) RA, (16) OC (O) N (RA) RB, (17) SRA, (18) S (O) RA, (19) S (O) 2RA, (20) S (O) 2N (RA) RB, (21) N (RA) S (O) 2RB, (22) N (RA) S (O ) 2N (RA) RB, (23) N (RA) C (O) RB, (24) N (RA) C (O) N (RA) RB, (25) N (RA) C (O) -C (O) N (RA) RB, (26) N (RA) CO2RB, (27) N (RC) RD, (28) C (O) N (RC) RD, (29) OC (O) N (RC) RD, (30) S (O) 2N (RC) RD, (31) N (RA) S (O) 2N (RC) RD, (32) N (RA) C (O) N (RC) RD, (33) N (RA) C (O) -C (O) N (RC) RD, (34) CycA, (35) -O-CycA, (36) ArilA, or (37) HetA; R3 is H, C1-6 alkyl, halogen, CN, C1-6 fluoroalkyl, OH, O-C1-6 alkyl or O-haloalkyl C1-6; each of R4 and R5 is independently selected from: |
| priorityDate | 2012-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 194.