| abstract |
Compound of formula (II) or salt thereof: ** Formula ** wherein R1 is selected from the group consisting of substituted or unsubstituted C2-8 alkyl, substituted or unsubstituted C1-8 alkoxy, substituted or unsubstituted C1-8 alkylamino substituted, and substituted or unsubstituted C3-10 heterocyclyl; R2 is H, F, Cl or C1-8 substituted or unsubstituted alkoxy; or R1 and R2 together with the carbon atoms to which they are attached form a non-aromatic carbocyclic ring or a heterocyclic ring; R3 is H, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C1-8 alkoxy, or halo; R4 is H or F; R5 is H, F, Cl or -CH3; R6 is H, halo, -CN, -CO2Ra, -CONH2, -NH2, substituted or unsubstituted C1-8 aminoalkyl, substituted or unsubstituted C1-8 alkyl, or substituted or unsubstituted C1-8 alkoxy; Ra is H or substituted or unsubstituted C1-8 alkyl; wherein R5 and R6 can together form a carbocyclic ring; L is a bond, -CH2-, or -CH (CH3) -; and Z is selected from the group consisting of ** Formula ** and N-oxides thereof; wherein the group Z may be unsubstituted or substituted with 1 to 3 independently selected R8 substituents; each R8 is independently selected from the group consisting of H, halo, -CN, -OH, oxo, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C1-8 alkoxy, -NR20R21, substituted or unsubstituted aryl, substituted heteroaryl or unsubstituted, and substituted or unsubstituted heterocyclyl; and R20 and R21 are each independently H or C1-8 alkyl substituted or unsubstituted. |