| abstract |
A compound having the formula I: ** (See formula) ** or a pharmaceutically acceptable salt or solvate thereof, wherein: W1 and W2 are N and W3 is CR3; or A1 is substituted pyridyl having one or two substituents or substituted phenyl having one, two or three substituents; wherein the pyridyl is substituted with one or two substituents independently selected from halo, nitro, cyano, hydroxy, amino, alkylamino, dialkylamino, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, aryloxy, aralkyloxy, alkylthio, carboxamido, sulfonamido, alkylcarbonyl, arylcarbonyl, alkylsulfonyl, arylsulfonyl, ureido, guanidino, carboxy, carboxyalkyl, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, alkoxyalkyl, (dialkylamino) alkyl, (alkylamino) alkyl, ( (cyano) alkyl, (carboxamido) alkyl, mercaptoalkyl, (heterocycle) alkyl, and (heteroaryl) alkyl; wherein phenyl is substituted with one, two, or three independently selected substituents of halo, nitro, cyano, hydroxy, amino, alkylamino, dialkylamino, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, aryloxy, aralkyloxy, alkylthio, carboxamido, sulfonamido, alkylcarbonyl, arylcarbonyl, alkylsulfonyl, arylsu lfonyl, ureido, guanidino, carboxy, carboxyalkyl, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, alkoxyalkyl, (amino) alkyl, hydroxyalkylamino, (alkylamino) alkyl, (dialkylamino) alkyl, (cyano) alkyl, (carboxamido ) alkyl, mercaptoalkyl, (heterocycle) alkyl or (heteroaryl) alkyl; X is -O-; A2 is selected from the group consisting of: a) optionally substituted aryl; b) optionally substituted heteroaryl; c) optionally substituted heterocycle; and d) optionally substituted cycloalkyl; E is selected from the group consisting of: a) hydroxy; b) alkoxy; and c) -NR1R2; ... |