http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2641372-T3
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f1be1a0992503ed3aafd1a9ba83865f8 |
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4409 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 |
| filingDate | 2013-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d2bda1252fb76a683fe08ebd44d007e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41d542e897a02550fc05ec5ecd9c2b8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06040a950f437dcd4f8f41cc2b107441 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb989960e8d4490f5f7382879e84060b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f219ad1e611d5a32ddbae2ca4cfaf88 |
| publicationDate | 2017-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2641372-T3 |
| titleOfInvention | Viral replication inhibitors, their preparation process and their therapeutic uses |
| abstract | Compound according to formula (I): ** Formula ** in which: * R1 and R6, identical or different, independently represent a hydrogen atom; - CN; -OH; -CF3; a halogen atom; a linear or branched C1-C3 alkyl or C1-C3 linear or branched heteroalkyl; * R2, unsubstituted or substituted by at least one T1, represents a partially or totally unsaturated or aromatic 5, 6 or 7-membered carbocycle; a partially, totally unsaturated or aromatic 5, 6 or 7-membered heterocycle; a partially or totally unsaturated or aromatic 5, 6 or 7 membered carbocycle fused with a saturated, partially or totally unsaturated or aromatic 5, 6 or 7 membered carbocycle; a partially or totally unsaturated or aromatic 5, 6 or 7 membered carbocycle fused with a saturated, partially or totally unsaturated or aromatic 5, 6 or 7 membered heterocycle; a partially or totally unsaturated or aromatic 5, 6 or 7-membered heterocycle condensed with a saturated, partially or totally unsaturated or aromatic 5, 6 or 7-membered carbocycle; a partially or totally unsaturated or aromatic 5, 6 or 7-membered heterocycle fused with a saturated, partially or totally unsaturated or aromatic 5, 6 or 7-membered heterocycle; * R3, unsubstituted or substituted by at least one T2, represents an aryl group; a condensed aryl with a saturated, partially or totally unsaturated or aromatic carbocycle of 5, 6 or 7 members; an aryl condensed with a saturated, partially or totally unsaturated or aromatic 5, 6 or 7-membered heterocycle; an aryl condensed with a saturated, partially or completely unsaturated or aromatic 4, 5, 6 or 7-membered heterocycle and also condensed with a saturated, partially or totally unsaturated or aromatic 4, 5, 6 or 7-membered heterocycle; a heteroaryl; a condensed heteroaryl with a saturated, partially or totally unsaturated or aromatic carbocycle of 5, 6 or 7 members; a heteroaryl fused to a saturated, partially or totally unsaturated or aromatic 5, 6 or 7-membered heterocycle; a C5-C7 cycloalkenyl; a C5-C7 cycloalkenyl fused to a saturated, partially or totally unsaturated or aromatic 4, 5, 6 or 7-membered heterocycle; or a saturated, partially or totally unsaturated or aromatic 5, 6 or 7-membered heterocycle; * R4 represents a linear or branched C1-C6 alkyl; a linear or branched C1-C6 fluoroalkyl or a C3-C6 cycloalkyl; * R5 represents a halogen atom; -CF3; a linear or branched C1-C6 alkyl; a linear or branched C2-C6 alkenyl; a linear or branched C2-C6 alkynyl; a linear or branched fluoroalkyl; a C3-C6 cycloalkyl; -CH2OH; or -CH2-OCH3; * T1 independently represents a hydrogen atom; a halogen atom; an alkyl; - (X) x-C1-C6 alkyl; a linear or branched fluoroalkyl; a linear or branched fluoroalkyl -OC1-C3; - (X) x C3-C6 cycloalkyl; - (X) x- (CT5T6) and C3-C6 cycloalkyl; - (X) x- (CT5T6) y-aryl; - (X) x- (CT5T6) and CN; - (X) x- (CT5T6) yOT3; - (X) x- (CT5T6) and ST3; - (X) x- (CT5T6) and S (O) T3; - (X) x- (CT5T6) and S (O) 2T3; - (X) x- (CT5T6) and NT3T4; - (X) x- (CT5T6) and C (O) T3; - (X) x- (CT5T6) and C (O) OT3; - (X) x- (CT5T6) and C (O) NT3T4; - (X) x- (CT5T6) and NT3C (O) NT3T4; - (X) x-CT5T6) and NT3C (O) T4; - (X) x (CT5T6) and NT3C (O) OT4; - (X) x- (CT5T6) andOC (O) NT3T4; - (X) x- (CT5T6) and S (O) 2NT3T4 or - (X) x- (CT5T6) and NT3S (O) 2T4; * T2 independently represents a hydrogen atom; a halogen atom; a linear or branched -OC1-C3 alkyl; a linear or branched C1-C3 fluoroalkyl; a linear or branched fluoroalkyl -OC1-C3; a linear or branched C1-C3 alkyl; or -CN; optionally two T2 geminals form with the carbon atom to which they are attached, a C3-C7 cycloalkyl; * X independently represents an oxygen atom; a sulfur atom; NT3; S> = O or S (O) 2; * T3 and T4, identical or different, independently represent a hydrogen atom; a linear or branched C1-C6 alkyl or a C3-C6 cycloalkyl; optionally T3, T4 and the nitrogen atom to which they are attached form a C4-C6 heterocycloalkyl; * T5 and T6, identical or different, independently represent a hydrogen atom; a fluorine atom or a linear or branched C1-C3 alkyl or a C3-C6 cycloalkyl; optionally T5, T6 and the carbon atom to which they are attached form a cyclopropyl; * x independently represents 0 or 1; * and independently represents 0, 1, 2 or 3; and a racemate, enantiomer, atropisomer, diastereoisomer or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2012-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID467213996 |
Total number of triples: 69.