http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2641210-T3
Outgoing Links
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| filingDate | 2014-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4535a4eae8bb559ed558aea0639c638c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9709d20d9e46d0d882816ef2f63447fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_903c59a9f5c756585394ecbba0db942a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4f3b5e6104d129f58a5f517978ab37c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d2e92cf4711c6a42494f81603f2bd2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcdd1f1b419b833bf05999d8f6dc08a2 |
| publicationDate | 2017-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2641210-T3 |
| titleOfInvention | Tetrazolone derivatives |
| abstract | A compound of formula (I) ** Formula ** in which R1 is n-propyl, iso-butyl, cyclopropyl, 3-fluorophenyl, 6-chloropyridin-3-yl, 3-chlorophenyl, 4-chlorophenyl, 3-trifluoromethoxyphenyl , 2- (trifluoromethyl) phenyl, 3- (trifluoromethyl) phenyl, 4- (trifluoromethyl) phenyl, 2,6-difluorophenyl, 2,5-difluorophenyl, 3,4-difluorophenyl, 3,5-difluorophenyl, 3-methylphenyl, 4-methylphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 2,3-dichlorophenyl, 1-methylindolyl or 3-bromophenyl; R2 is -C (O) NR3R4 or R5; one of R3 and R4 is hydrogen, alkyl, cycloalkyl or alkoxyalkyl and the other is - (CH2) n-R6; or R3 and R4, together with the nitrogen atom to which they are attached, form a heterocyclyl or substituted heterocyclyl, in which the heterocyclyl is piperidinyl, morpholinyl, pyrrolidinyl, 3,4-dihydro-1H-isoquinolinyl, azetidinyl, piperazinyl, 1 , 1-dioxothiomorpholinyl or 2-oxa-8-aza-spiro [4.5] decyl, and wherein the substituted heterocyclyl is heterocyclyl substituted with a substituent selected from halogen, alkyl, cyano, alkoxyalkyl, aminocarbonyl, dialkylaminocarbonyl, dialkylaminocarbonylalkyl, alkylamino, Phenyl, Halophenyl, Phenylalkyl, Halophenylalkyl, Methylpyrazolyl, Methylisoxazolyl, Alkoxyalkyl, Alkylcarbonylamino, Alkylcarbonyl, Alkoxycarbonyl, Alkyl [1,2,4] Oxadiazolyl, alkylaryl-alkylalkyl, alkylaryl) 20 substituents independently selected from alkyl, halogen, alkoxycarbonyl, and alkoxycarbonylamino; R5 is halophenylalkyl, alkoxycarbonylpiperidinyl, alkoxycarbonylalkyl, (alkylsulfonyl) (alkyl) [1,2,4] triazolylalkyl or morpholinylcarbonylalkyl; provided that 1-Cyclopropyl-4- (pyrrolidin-1-carbonyl) -1,4-dihydro-tetrazol-5-one; 1-Cyclopropyl-4- (2-methyl-pyrrolidin-1-carbonyl) -1,4-dihydro-tetrazol-5-one; 1-Cyclopropyl-4- (2,5-dimethyl-pyrrolidin-1-carbonyl) -1,4-dihydro-tetrazol-5-one; 1-Cyclopropyl-4- (2,6-dimethyl-piperidin-1-carbonyl) -1,4-dihydro-tetrazol-5-one; 4-Cyclopropyl-5-oxo-4,5-dihydro-tetrazol-1-carboxylic acid benzyl isopropyl amide; [4- (4-Chloro-phenyl) -5-oxo-4,5-dihydro-tetrazol-1-yl] -acetic acid ethyl ester; 2- [4- (4-Chloro-phenyl) -5-oxo-4,5-dihydro-tetrazol-1-yl] -propionic acid ethyl ester; 3- [4- (3-Chloro-phenyl) -5-oxo-4,5-dihydro-tetrazol-1-yl] -propionic acid methyl ester; 1- (2,3-Dichlorophenyl) -4- (2-methyl-piperidin-1-carbonyl) -1,4-dihydro-tetrazol-5-one; 1- (2,6-Difluorophenyl) -4- (3,4-dihydro-1H-isoquinolin-2-carbonyl) tetrazol-5-one; 4- (2,6-Difluorophenyl) -5-oxo-N-phenyl-N-propyl-tetrazol-1-carboxamide; 4- (2,6-Difluorophenyl) -N-ethyl-5-oxo-N-phenyl-tetrazol-1-carboxamide; 4- (2,6-Difluorophenyl) -N-methyl-5-oxo-N-phenyl-tetrazol-1-carboxamide; 4- (2,6-Difluorophenyl) -N-isopropyl-5-oxo-N-phenyl-tetrazol-1-carboxamide; N-Cyclohexyl-4- (2,6-difluorophenyl) -5-oxo-N-phenyl-tetrazol-1-carboxamide; 4- (2,6-Difluorophenyl) -N-methyl-5-oxo-N- (2-pyridyl) tetrazol-1-carboxamide; N, 4-Dicyclopropyl-5-oxo-N-phenyl-tetrazol-1-carboxamide; N-Butyl-4-cyclopropyl-5-oxo-N-phenyl-tetrazol-1-carboxamide; 4-Cyclopropyl-N-isobutyl-5-oxo-N-phenyl-tetrazol-1-carboxamide; 4-Cyclopropyl-N-isopropyl-5-oxo-N-phenyl-tetrazol-1-carboxamide; 4-Cyclopropyl-5-oxo-N-phenyl-N-propyl-tetrazol-1-carboxamide; 4-Cyclopropyl-N-methyl-5-oxo-N-phenyl-tetrazol-1-carboxamide; 4-Cyclopropyl-N-ethyl-5-oxo-N-phenyl-tetrazol-1-carboxamide; 4-Cyclopropyl-5-oxo-N-phenyl-N-sec-butyl-tetrazol-1-carboxamide; N- (1-Benzyl-2-methyl-propyl) -4-cyclopropyl-5-oxo-N-phenyl-tetrazol-1-carboxamide; 1- (2-Methylpiperidin-1-carbonyl) -4- (p-tolyl) tetrazol-5-one; 1- (2-Methylpiperidin-1-carbonyl) -4- (m-tolyl) tetrazol-5-one; N-Isopropyl-5-oxo-N-phenyl-4-propyl-tetrazol-1-carboxamide; 1- (4-Chlorophenyl) -4 - [(2-fluorophenyl) methyl] tetrazol-5-one; 1- (4-Chlorophenyl) -4 - [(3-fluorophenyl) methyl] tetrazol-5-one; 1- (4-Chlorophenyl) -4 - [(3-chlorophenyl) methyl] tetrazol-5-one; 1 - [(4-Bromophenyl) methyl] -4- (4-chlorophenyl) tetrazol-5-one; and methyl 3- [5-Oxo-4- (p-tolyl) tetrazol-1-yl] propanoate are excluded; where "alkyl", alone or in combination, means a straight chain or branched chain alkyl group having 1 to 8 carbon atoms; "cycloalkyl", alone or in combination, means a cycloalkyl ring with 3 to 8 carbon atoms; and "alkoxy", alone or in combination, means a group of the formula alkyl-O- in which the term "alkyl" has the meaning previously given. |
| priorityDate | 2013-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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