| abstract |
A compound of Formula I: ** Formula ** or a stereoisomer, a tautomer, a pharmaceutically acceptable salt or a solvate thereof, wherein: W is O or S; R0 is R1; Y is S or -CR8> = CR9-; R1 is independently selected from the group consisting of: H, halo, C1-C4 alkyl, C2-C3 alkenyl, C2-C3 alkynyl, C3-C4 cycloalkyl, C1-C4 alkoxy, C1-C2 alkoxy-C1-C2 alkyl, tetrahydrofuran-2-yl, C1-C4 alkylthio, C1-C4NH- alkyl, (C1-C4 alkyl) 2N-, halo-C1-C2 alkyl, containing from 1 to 5 halogens, wherein halo is F or Cl, halo -C3-C4 cycloalkyl, halo-C1-C2 alkoxy and halo-C1-C2 alkylthio; R8 and R9 are independently selected from the group consisting of: H, halo, C1-C4 alkyl, C1-C4 alkoxy, halo-C1-C2 alkyl, halo-C1-C2 alkoxy, CN, and OH; with the proviso that at least one of R1, R8 and R9 is different from H; R2 is selected from the group consisting of: H, halo, C1-C4 alkyl, C1-C4 alkoxy and cyano; X1 is selected from the group consisting of CH, N or CR10; X2, X3 and X4 are independently selected from CR3 or N; R3 is selected from the group consisting of H, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 alkoxy, C1-C4 alkylthio, halo, OH, CN, OCF3, OCHF2, OCH2F, C1 alkoxy -C2-C1-C2 alkoxy, halo-C1-C3 alkyl, containing from 1 to 5 halogens, benzyloxy substituted with 0 to 3 groups independently selected from the group consisting of halo, C1-C4 alkoxy, C1-C4 alkyl, cyclopropyl, CF3, OCF3, 5- or 6-membered heteroaryl, OH, OCHF2, C1-C4 di-alkylamino and cyano, and - (CH2) n 1-phenyl substituted with 0 to 3 groups independently selected from the group consisting of halo , C1-C4 alkoxy, C1-C4 alkyl, cyclopropyl, CF3, OCF3, 5- or 6-membered heteroaryl, OH, OCHF2, C1-C4 di-alkylamino and cyano; R4 and R5 are independently selected from H and C1-C6 alkyl, or R4 and R5 can be taken together with the carbon to which they are attached to form a C3-C7 cycloalkyl ring; ** Formula ** |