http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2640616-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f52c68e4149a6c462b850d4e7cc2b2f9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 |
| filingDate | 2013-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb3fca283be98bc89f73090b9541ed0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb15d09796702de7418b20714018f6db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2edbf9022d8d83a84e9fcf46085724ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_114a7cdde5a8bf78d2bfbc85b0d92d9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e8c4417b32270f68d55f4aa8848122e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46085eed1f39fc48aa53b9f24b126e5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e2c2ee4e7934e6dd007aadd60636e27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a45af40da0cb20d6b2a154f2174b8968 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82bf5398ae34f7fce09eaf1701ee82e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53dcb0439d2e20cf6c609beeddafb32c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aefd456d637a37c0cb915ebe81bcd2ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e0b022b98470ab7eb2eec57ebf8a879 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d702ffb9b0a7dddc3a822af270dedde http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cefdd0d7fab0a76a42f9d73bc5f9203 |
| publicationDate | 2017-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2640616-T3 |
| titleOfInvention | Imidazo [1,2-a] hydroxy substituted pyridine-3-carboxamides and their use as stimulators of soluble guanylate cyclase |
| abstract | Compound of formula (I) ** Formula ** in which A represents CH2, CD2 or CH (CH3), R1 represents (C4-C6) alkyl, (C3-C7) cycloalkyl, pyridyl or phenyl, and alkyl can be substituted ( C4-C6) up to six times with fluorine, and cycloalkyl (C3-C7) may be substituted with one to four substituents independently selected from the group of fluorine, trifluoromethyl and (C1-C4) alkyl, and pyridyl may be substituted with 1 to 3 substituents independently selected from the group of fluorine, trifluoromethyl and (C1-C4) alkyl, and phenyl may be substituted with 1 to 4 substituents independently selected from the group of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, C1-alkyl. -C4), (C3-C6) cycloalkyl, (C1-C4) alkoxy, difluoromethoxy and trifluoromethoxy or may be substituted by 2 adjacent carbon atoms of the phenyl with a difluoromethylenedioxy bridge, R2 represents hydrogen, (C1-C4) alkyl, cyclopropyl, mo nofluoromethyl, difluoromethyl or trifluoromethyl, R3 represents a group of the formula ** Formula ** in which * represents the point of attachment to the carbonyl group, L1A represents a bond or (C1-C4) alkanediyl, in which alkanediyl (C1-C4 ) may be substituted with 1 to 3 substituents independently selected from the group of fluorine, trifluoromethyl, (C1-C4) alkyl, (C3-C7) cycloalkyl, hydroxy and (C1-C4) alkoxy, L1B represents a bond or alkanediyl ( C1-C4), L1C represents a bond or (C1-C4) alkanediyl, in which (C1-C4) alkanediyl can be substituted with 1 to 3 substituents independently selected from the group of fluorine, trifluoromethyl, (C1-C4 alkyl) ), (C3-C7) cycloalkyl, hydroxy and (C1-C4) alkoxy, R7 represents (C1-C6) alkyl or (C2-C6) alkynyl, in which (C1-C6) alkyl is substituted with 1 to 3 substituents independently selected from the group of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy and benzyloxy, in where benzyloxy is substituted with 1 to 3 halogen substituents, and in which also (C1-C6) alkyl may be substituted with hydroxy, R8 represents hydrogen or (C1-C4) alkyl, where (C1-C4) alkyl may be substituted with hydroxy, R9 represents hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C3-C7) cycloalkyl, (C1-C4) alkoxycarbonyl, heteroaryl of 5 or 6 members or phenyl, in which (C1-C6) alkyl can be substituted with 1 to 3 substituents independently selected from the group of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, (C1-C4) alkoxycarbonyl ), (C1-C4) alkylthio, (C1-C4) alkylsulfonyl, phenyl, phenoxy and benzyloxy, in which phenyl, phenoxy and benzyloxy in turn can be substituted with 1 to 3 halogen substituents, in which (C3- C7) can be substituted with 1 or 2 substituents independently selected from the group of fluorine, trifluoromethyl, alkyl (C1-C4) and (C1-C4) alkoxy, and in which 5- or 6-membered phenyl and heteroaryl may be substituted with 1 to 3 substituents 5 independently selected from the group of halogen, cyano, trifluoromethyl, (C1-alkyl) -C4), (C1-C4) alkoxy and (C1-C4) alkylsulfonyl, R10 represents hydrogen or (C1-C4) alkyl, in which (C1-C4) alkyl may be substituted with hydroxy, or R9 and R10 together with the carbon atom to which they are attached form a 3-7 membered carbocycle or a 4-7 membered heterocycle, in which the 3-7 membered carbocycle and the 4-7 membered heterocycle may in turn be replaced with 1 or 2 substituents independently selected from the group of fluorine and (C1-C4) alkyl, R4 represents hydrogen, R5 represents hydrogen, halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C1-C4) alkyl, cycloalkyl (C3-C7) ), (C2-C4) alkynyl, difluoromethoxy, trifluoromethoxy, (C1-C4) alkoxy, amino, 4 to 7 ml heterocyclyl embros or 5- to 6-membered heteroaryl, R6 represents hydrogen, cyano or halogen, as well as their N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. |
| priorityDate | 2012-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1500.