| abstract |
A homogeneous non-aqueous solution comprising a solubilized lipophilic pharmaceutical agent and an amphiphilic liquid polymer solvent, which is liquid polyethylene glycol (PEG), the formulation being basically free of non-polymeric organic solvents, water and non-solubilized particles, in which the agent Lipophilic pharmaceutical is an antifungal azol or is the anticancer agent Busulfan (1,4-butanediol dimethanesulfonate), and in which the solubilized lipophilic pharmaceutical agent has a concentration of at least 2 mg / ml, in which the solution remains stable and basically free of particles not solubilized for at least 40 days when stored at room temperature, and in which the solution does not comprise a surfactant. |