| abstract |
A method for detecting a clinically significant immune response of a VLA-4 binding antibody in a subject, the method comprising determining whether a biological sample of a subject to whom a VLA4 binding antibody has been administered contains at least one threshold level. , clinically significant, of 500 ng / ml of a soluble antibody that binds to the VLA-4 binding antibody, where the presence of at least the threshold level of the soluble antibody is indicative of a decrease in efficacy or lack of efficacy of the VLA-4 binding antibody. |