| abstract |
A composition for iontophoretic transdermal administration of at least one cationic active agent or a salt thereof, comprising: - said at least one cationic active agent or a salt thereof, wherein the total content of said cationic active agent or a salt thereof amounts to 0.1 to 20% by weight, with respect to the total weight of the composition, and in which said cationic active agent is selected from cationic indole compounds and salts thereof; - at least one polyamine in the form of a polyamine salt, wherein said polyamine salt is obtained by combining or reacting said polyamine with an organic acid, said organic acid comprising at least one saturated C6 to C14 fatty acid; - water or an aqueous mixture of solvents, in which the proportion of water or aqueous mixture of solvents is at least 15% by weight, with respect to the total weight of the composition; - optionally, one or more additives; wherein said composition is a liquid aqueous composition or a hydrogel and is adsorbed on an adsorbent material. |