http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-263931-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 |
| filingDate | 1961-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-263931-A1 |
| titleOfInvention | PROCEDURE FOR OBTAINING THIAXANTHENE DERIVATIVES |
| abstract | The invention comprises thiaxanthene derivatives of the general formula (I): <FORM:0941992/C2/1> (wherein R1 and R2 each represent an alkyl group containing from 1 to 6 carbon atoms, and n is 1 or 2) and their acid addition salts, pharmaceutical compositions containing them, and their preparation by reacting a 2 - alkylmercapto -thiaxanthone -(9) with a 2-(11-alkylpyrrolidyl-21)-ethyl magnesium halide or 2-(11-alkylpiperidyl-21)-ethyl magnesium halide, hydrolising the product, and treating the resulting thiaxanthenol derivative: <FORM:0941992/C2/2> with a dehydrating agent capable of removing the elements of water from it, optionally followed by salt formation. The compounds (I) exhibit geometrical and optical isomerism, and the invention includes the separation of the isomers. 2- Methylmercaptothiaxanthone-(9) is prepared by condensing thiosalicylic acid with pbromothioanisole in the presence of copper and potassium carbonate, converting the reaction product to the acid chloride by means of thionyl chloride and cyclising with aluminium chloride in nitrobenzene. 2-Ethylmercaptothiaxanthone-(9) is prepared similarly. The compounds of the invention potentiate narcosis and/or have an adrenolytic and/or sedative effect 2-methylmercapto-9-[21-(N-methylpiperidyl-211) - ethylidene-11]-thiaxanthene has a hypotensive effect. |
| priorityDate | 1960-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.