http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2638915-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-04 |
| filingDate | 2012-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7e0cd1e0c8d0678e8d4c45324a3a35c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37263258158373edadf7a41f997f5ba2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32f313348cda116a43ff5300a5e65ed4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_351d75b9b8ad1c8d3db70bc9e12b0e55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df3f234bc07b7e39a5c9f5226a214dc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_702dde41fa8a82af4fca473e0a34cf2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e98472f2bd026653ecca9e3071f3e602 |
| publicationDate | 2017-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2638915-T3 |
| titleOfInvention | Method of preparing compounds used as SGLT-22 inhibitors |
| abstract | A process for the preparation of a compound of formula (I-S) ** Formula ** or a pharmaceutically acceptable salt thereof; comprising ** Formula ** reacting a compound of formula (V-S), wherein PG1 is an oxygen protecting group with an acylation reagent; wherein the acylation reagent is present in an amount in the range of 1.5 to 3.0 molar equivalents; in the presence of a carbonyl source; in a first organic solvent; at a temperature in the range of about room temperature at 40 ° C; to produce the corresponding compound of formula (VI-S); ** Formula ** react the compound of formula (VI-S) with a compound of formula (VII-S), wherein A1 is MgBr or MgCl; 60 in an anhydrous organic solvent; to produce the corresponding compound of formula (VIII-S); ** Formula ** react the compound of formula (VIII-S) with a reducing agent; in the presence of a Lewis acid; in a second organic solvent; to produce the corresponding compound of formula (IX-S); ** Formula ** of-protecting the compound of formula (IX-S); to produce the corresponding compound of formula (I-S). |
| priorityDate | 2011-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 181.