| abstract |
Peptides of general formula R1-AA-R2 capable of regulating neuronal exocytosis, its stereoisomers and mixtures thereof, racemic or not, and the cosmetically or pharmaceutically acceptable salts thereof, where AA is a sequence of 3 to 40 amino acids adjacent contained in the amino acid sequence of the SNAP-25 protein, R1 is selected from the group consisting of H or groupalkyl, aryl, aralkyl or acyl; and R2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or not with aliphatic or cyclic groups, with the proviso that when R1 is H or acetyl, R2 is not unsubstituted amino, hydroxyl or thiol. A method of obtaining, cosmetic or pharmaceutical compositions that contain them and their use to treat those conditions that require the regulation of neuronal exocytosis, preferably to treat the skin. |