| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_57f3e2af72b2933c004ed61dfccaaee1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6841 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57434
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2012-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29dc9a21e9863aa497b2d8e5e000c6c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_766be27689fb201ee9373753341be15b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7d66003eba392dbc837d366c37061e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6951bae7c157f0b61777413173b7a17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c3ec14e5c9099ec79d5fc1e24e81f9a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36e768a5bed53d9be23c73b3e148b758
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3ef281e0ad80aa655bce3bc25f38739 |
| publicationDate |
2017-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2638089-T3 |
| titleOfInvention |
Presence of ERG gene rearrangements and protein overexpression in low-grade NIP (NIP-BG) in prostate biopsies |
| abstract |
A method for the early stage diagnosis of prostate cancer in a subject, comprising determining the presence of low-grade prostatic intraepithelial neoplasia (NIP-BG) in said subject, comprising: (a) providing a sample of the subject, having previously considered the negative subject for prostate cancer; (b) detecting the presence or absence in the sample of a gene fusion having a 5 'portion of a transcriptional regulatory region of an androgen-regulated gene and a 3' portion of an ERG gene by detecting chromosomal rearrangements of Genomic DNA using a nucleic acid hybridization technique, and (c) detecting the level of ERG protein expression using an immunohistochemistry assay in which the presence in the sample of both the gene fusion detected in step (b) and of the ERG overexpression detected in step (c) is indicative of low-grade PIN in the subject. |
| priorityDate |
2011-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |