| abstract |
A CTP modified polypeptide consisting of one erythropoietin (EPO), and three CTPs, wherein said CTP are carboxy-terminal peptides of chorionic gonadotropin of the beta subunit of human chorionic gonadotropin, in which the first CTP is bound to the amino terminus of said EPO, and the second and third CTP are attached to the carboxy end of said EPO, wherein said CTP comprises the SSSSKAPPPS amino acid sequence, wherein said EPO lacks a signal peptide, and wherein the amino acid sequence of said CTP modified polypeptide comprises amino acid sequence 28-277 of SEQ ID NO: 3 or amino acids 28-249 of SEQ ID NO: 6. |