abstract |
A fusion protein comprising the formula: Ab- (PL-Ag) x; Ab- (Ag-PL) x; Ab- (PL-Ag-PL) x; Ab- (Ag-PL-Ag) x; Ab- (PL-Ag) x-PL; or Ab- (Ag-PL) x-Ag; wherein Ab is an antibody or antibody fragment that specifically binds to CD40; PL is at least one peptide connector selected from the group consisting of SSVSPTTSVHPTPTSVPPTPTKSSP (SEQ ID NO: 11), PTSTPADSSTITPTATPTATPTIKG (SEQ ID NO: 12), TVTPTATATPSAIVTTITPTATTKP (SEQ ID NO: 13AT), and TNGSIT SEAT IDAT (NPT) NPT: NAPTPS (NPT) NPTPPS (NPT) IDP: Ag is at least one cancerous antigen; and x is an integer from 1 to 20. |