| abstract |
A nucleic acid molecule, wherein said molecule comprises a 32 to 100 bp double chain part, has at least one free end, lacks CpG, has less than 70% sequence identity with any gene in the human genome, it comprises one or more phosphorothioates or nucleotides with a methylphosphonate skeleton at the end of each chain or at least at the 3 'end of the chain, and wherein said molecule is a substrate to bind at least the Ku protein involved in the NHEJ pathway of DSB double chain break repair, where the double chain part has the sequence of Dbait32Hc molecules (SEQ ID No 17), Dbait32Hc-3'mp (SEQ ID No 19), Dbait32Hc-5'3'mp ( SEQ ID No 20), Dbait32Hc-Cy3 ID No 23) and Dbait32Hc-Cy5 (SEQ ID No 24). |