Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_324f02bbaa9087f036e446bb1c3183a3 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-50 |
filingDate |
2012-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2017-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5ccfadd39cb8a771407637219fb5d35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e507cf2c3adec8fa920c36e8e4baf14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ba7e267052605c8bd83e5d205d8d9a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e05572b798b158cfa1a4e0087ea33a14 |
publicationDate |
2017-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
ES-2632786-T3 |
titleOfInvention |
Proteasome desubiquitination inhibitor test |
abstract |
Method for examining a compound to determine if the compound is a high specificity proteasome desubiquitination inhibitor, the method comprising contacting the compound with human 19S regulatory particles (RP 19S) of 26S proteasome and determining whether the compound inhibits the activity of deubiquitination enzymes (DUB) UCHL5 and USP14, and an additional step of determining whether the compound affects the activity of associated non-proteasomal DUB enzymes, in which the inhibition of the activities of UCHL5 and USP14 and the unaffected activity of Associated non-proteasomal DUB enzymes indicates that the compound is a high specificity proteasome desubiquitination inhibitor. |
priorityDate |
2011-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |