| abstract |
An isolated antibody or antigen-binding fragment thereof that specifically binds to amino acids 1-85 of SEQ ID NO: 1, wherein said antibody or antigen-binding fragment thereof is internalized after binding to cells expressing C4.4a, and wherein said antibody or antigen-binding fragment thereof comprises the variable heavy chain CDR sequences: H-CDR1 comprising SEQ ID NO: 45, H-CDR2 comprising SEQ ID NO: 46 and H-CDR3 comprising SEQ ID NO: 47, and wherein said antibody or antigen-binding fragment thereof comprises the variable light chain CDR sequences: L-CDR1 comprising the SEQ ID NO: 48, L-CDR2 comprising SEQ ID NO: 49, and L-CDR3 comprising SEQ ID NO: 50. |