http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2632600-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c82f1477b71e93f1ff6e9b27d67ec77 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D253-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65031 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6503 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D253-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-18 |
filingDate | 2013-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2017-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37c5643bd92f6f879ec6ac322481b223 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbfa1dbd497ea6a533442cc0d874161e |
publicationDate | 2017-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2632600-T3 |
titleOfInvention | Neprilysin inhibitors |
abstract | A compound of formula XII: ** Formula ** where: (i) Ra is H; Rb is Cl; X is: ** Formula ** and R2 is H, R4 is -OH, and R7 is selected from -CH2CF3, - (CH2) 2CF3, -CH2CF2CH3, -CH2CF2CF3, -C (CH3) (CF3) 2, - CH (CH2CH3) CF3, -CH (CH3) CF2CF3, - (CH2) 2-3OH, -CH2CH (NH2) COOCH3, - (CH 15 2) 2OCH3, -CHRcOC (O) -C1-4 alkyl, - CHRcOC (O ) O-C2-4 alkyl, -CHRcOC (O) O-cyclohexyl, -C2-4-N alkylene (CH3) 2, -CH2OC (O) CHRd-NH2, - CH2OC (O) CHRd-NHC (O) O -C1-6 alkyl, benzyl, and: ** Formula ** or R2 is H, R4 is selected from -O-benzyl, -OCHRcOC (O) -C1-4 alkyl, -OCH2OC (O) CHRd-NH2, and - OCH2OC (O) CHRd-NHC (O) O-C1-6 alkyl, and R7 is selected from H and -CH2OC (O) CH3; or R2 is selected from -C (O) - C1-6 alkyl, -C (O) CHRd-NH2, -C (O) CHRd-NHC (O) O-C1-6 alkyl, and -P (O) ( ORe) 2, R4 is -OH, and R7 is H; or (ii) Ra is H; Rb is Cl; X is: ** Formula ** and R2 is H, R3 is -OH and R7 is selected from -CH2CF3, - (CH2) 2CF3, -CH2CF2CH3, -CH2CF2CF3, -C (CH3) (CF3) 2, - CH ( CH2CH3) CF3, -CH (CH3) CF2CF3, - (CH2) 2-3OH, -CH2CH (NH2) COOCH3, - (CH2) 2OCH3, -CHRcOC (O) -C1-4 alkyl, - CHRcOC (O) O- C2-4 alkyl, -CHRcOC (O) O-cyclohexyl, -C2-4-N alkylene (CH3) 2, -CH2OC (O) CHRd-NH2, - CH2OC (O) CHRd-NHC (O) O-C1 alkyl -6, benzyl, and: ** Formula ** or R3 is selected from -OC (O) CH2CH3, -OC (O) CH2CH (CH3) 2, -OC (O) -phenyl, -OCH2OC (O) CHRd- NH2, and - OCH2OC (O) CHRd-NHC (O) O-C1-6 alkyl, and R7 is H; or R2 is selected from -C (O) -C 1-6 alkyl, -C (O) CHRd-NH2, - C (O) CHRd-NHC (O) O-C1-6 alkyl, and -P (O) ( ORe) 2, R3 is -OH, and R7 is H; or (iii) Ra is H; Rb is Cl; X is: ** Formula ** and R2 is H, R3 is -OH and R7 is selected from -CH2CH3, -CH2CH (CH3) 2, -CH2CF3, - (CH2) 2CF3, -CH2CF2CH3, - CH2CF2CF3, -C ( CH3) (CF3) 2, -CH (CH2CH3) CF3, -CH (CH3) CF2CF3, - (CH2) 5 2-3OH, -CH2CH (NH2) COOCH3, - (CH2) 2OCH3, -CHRcOC (O) -alkyl C1-4, -CHRcOC (O) O-C2-4 alkyl, -CHRcOC (O) O-cyclohexyl, -C2-4-N alkylene (CH3) 2, - CH2OC (O) CHRd-NH2, -CH2OC (O ) CHRd-NHC (O) O-C1-6 alkyl, benzyl, and ** Formula ** or R2 is H, R3 is selected from -OC (O) CH2CH3, -OC (O) CH2CH (CH3) 2, - OC (O) -phenyl, -OCH2OC (O) CHRd-NH2, and - OCH2OC (O) CHRd-NHC (O) O-C1-6 alkyl, and R7 is H; or R2 is selected from -C (O) -C 1-6 alkyl, -C (O) CHRd-NH2, - C (O) CHRd-NHC (O) O-C1-6 alkyl, and -P (O) ( ORe) 2, R3 is -OH, and R7 is H; or (iv) Ra is F; Rb is Cl; X is ** Formula ** and R2 is H and R7 is selected from H, -CH2CH3, -CH2CF3, - (CH2) 2CF3, -CH2CF2CH3, -CH2CF2CF3, -C (CH3) (CF3) 2, - 20 CH ( CH2CH3) CF3, -CH (CH3) CF2CF3, - (CH2) 2-3OH, -CH2CH (NH2) COOCH3, - (CH2) 2OCH3, -CHRcOC (O) -C1-4 alkyl, - CHRcOC (O) O- C2-4 alkyl, -CHRcOC (O) O-cyclohexyl, -C2-4-N alkylene (CH3) 2, -CH2OC (O) CHRd-NH2, - CH2OC (O) CHRd-NHC (O) O-C1 alkyl -6, benzyl, and ** Formula ** or R2 is selected from -C (O) -C1-6 alkyl, -C (O) CHRd-NH2, -C (O) CHRd-NHC (O) O-alkyl C1-6, and -P (O) (ORe) 2, and R7 is H; or (v) Ra is H; Rb is Cl; X is |
priorityDate | 2012-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1407.