| abstract |
Vaccine comprising at least one mRNA encoding at least one antigen for use in the prophylaxis of an infectious disease in an elderly patient, with an age of at least 50 years, where - the treatment comprises the vaccination of the patient and the provocation of an immune response in said patient; - the G / C content of the coding region of or of the mRNAs is increased by at least 15% compared to the G / C content of the coding region of the respective wild-type coding sequence; and - the mRNA (s) are complexed with a polycationic compound. |