http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2631655-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e336e8f1c646b5e4212c9675d7f9d629 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-26 |
| filingDate | 2013-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_daaa6d9030c2a05fb072249e4c9bc1c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e4073b3aced6bafa493fb0a96feb349 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d87050611423b417fa2728aa6fb349d4 |
| publicationDate | 2017-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2631655-T3 |
| titleOfInvention | Procedure for manufacturing isoquinoline compounds |
| abstract | A process for preparing a compound of formula I or a stereoisomer or mixture of stereoisomers thereof: ** Formula ** comprising the process contacting a compound of formula II: ** Formula ** with a compound of formula III: ** Formula ** under sufficient reaction conditions to produce a compound of formula I; where Z is O, NR1 or S; R1 is selected from the group consisting of hydrogen and alkyl; R2 is selected from the group consisting of hydrogen and alkyl that is unsubstituted or substituted with one or more substituents independently selected from the group consisting of cycloalkyl, heterocyclyl, aryl and heteroaryl; R3 and R4 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, halo, hydroxy, cyano, -S (O) nN (R8) -R8, -NR8C (O) NR8R8 and -X1R8; in which X1 is oxygen, -S (O) n- or -NR9-; n is 0, 1 or 2; each R8 is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heteroaryl, substituted heteroaryl, heterocyclyl and substituted heterocyclyl provided that when X1 is -SO- or -SO2-, R8 it is not hydrogen; and R9 is selected from the group consisting of hydrogen, alkyl and aryl; or R3 and R4 together with the pending carbon atoms thereof, form a cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; R5 and R6 are independently selected from the group consisting of hydrogen, halo, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl and -X2R10; wherein X2 is oxygen, -S (O) n-, or -NR13-; n is 0, 1 or 2; R10 is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl and substituted heterocyclyl; and R13 is selected from the group consisting of hydrogen, alkyl and aryl; or when X2 is -NR13-, R10 and R13, together with the nitrogen atom to which they are attached, can be joined to form a substituted heterocyclyl or heterocyclyl group; and each R11 is independently selected from alkyl, benzyl and aryl, or two R11 together with the nitrogen atom to which they are attached form a 4-8 membered heterocyclyl or a heteroaryl |
| priorityDate | 2012-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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