| abstract |
A compound of formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, in which, independently for each case: R1 is H, C1-C6 alkyl, C1-C6 fluoroalkyl, C3-C8 cycloalkyl, CF3, heterocycloalkyl optionally substituted, aryl, heteroaryl, or a linear, branched or cyclic (C1-C8) -R9 chain in which up to two CH2 units can be replaced by O, CO, S, SO, SO2, N, CF2O NR8; R2 is C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkyl, fluoroalkyl, CF3, CHF2, OR a linear, branched or cyclic (C1-C8) -R9 chain in which up to two units CH2 can be replaced by O, CO, S, SO, SO2, N, CF2O NR8; R3 is C1-C6 alkyl or halo; R8 is H, C1-C6 alkyl, C3-C8 cycloalkyl, CF3, or a linear, branched or cyclic (C1-C8) -R9 chain in which up to two CH2 units can be replaced by O, CO, S, SO , SO2, N, CF2, or NR, or 2 R8 together with the atoms to which they are attached form a ring; R9 is H, CF3, CHF2, CH2F, CO2R, halo, OH, optionally substituted aryl, heteroaryl, C3-C8 cycloalkyl, heterocycloalkyl, N (R) 2, NRCOR, CON (R) 2, CN, or SO2R; R is H, C1-C6 alkyl, optionally substituted aryl, heteroaryl, C3-C8 cycloalkyl cycloalkyl, or heterocycloalkyl; Ring A is an optionally substituted aryl, heteroaryl or heterocyclic; N is an integer from 0 to 4 inclusive; and o is an integer from 0 to 4 inclusive. |