| abstract |
A method of determining the potential for a HBV to exhibit reduced sensitivity to a nucleoside analog, said method comprising the isolation of DNA or the corresponding mRNA from said HBV and the search for a mutation in the nucleotide sequence encoding HBV DNA polymerase , which results in at least one amino acid mutation of one or more of N / S / H584T, N / S / H584A and H584I being selected, the presence of such mutation being an indication of the probability of resistance to said nucleoside analog |