| abstract |
An isolated monoclonal antibody that binds to human OX40R, comprising: (a) a heavy chain CDR1 comprising an amino acid sequence of SEQ ID NO: 1; a heavy chain CDR2 comprising an amino acid sequence of SEQ ID NO: 2; and a heavy chain CDR3 comprising an amino acid sequence of SEQ ID NO: 3; or (b) a heavy chain CDR1 comprising an amino acid sequence of SEQ ID NO: 13; a heavy chain CDR2 comprising an amino acid sequence of SEQ ID NO: 14; and a heavy chain CDR3 comprising an amino acid sequence of SEQ ID NO: 15, wherein said isolated monoclonal antibody comprises 1, 2, 3 or 4 conservative amino acid substitutions in one or more CDR sequences of the heavy chain ; and wherein said isolated monoclonal antibody: (a) binds to human OX40R with a KD of 5 x 10-9 M or less; and (b) has agonist activity in human OX40R. |