http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2628046-T3
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-06 |
| filingDate | 2013-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec6c4af191a06d632a275c63843f2cf0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54af0e38854ef1a80eab420ecb39bddf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_708e544e9e5c6989b8ae04b0db0937c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e547716087e914ee0e81897ff2eab28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5387d77698727174c4b2aff39543e499 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cec1b4342a7e516c107e5a2ba613314c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_956ca97471f61db1edaecedb1988ddae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_279f5bd61dc1aa5ce990a3b9e8340f9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db12b9b1d9421729d240f780267a0800 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91562e33da33e59d8843f7c0848ba5ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2128b1aaee49e08ac4ae63cff0d789b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_595ab3e14b9e6b27f3c7265197c663c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21bc3375780d40edc390a45336c1ac27 |
| publicationDate | 2017-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2628046-T3 |
| titleOfInvention | Substituted tricyclic benzimidazoles as kinase inhibitors |
| abstract | A compound of formula (I) ** Formula ** wherein X1, X2 and X3 are each independently selected from the group consisting of H, F, Cl, Br, I, -OT1, - N (T2) (T3 ), -NHC (> = O) T4, nitro, cyano, cyclopropyl and -C1-3 alkyl, with the proviso that at least two substituents selected from X1, X2 and X3 are each independently selected from the group consisting of F, Cl, Br and I; Z1 and Z2 are each independently selected from the group consisting of H, -C1-6 alkyl, -OT1 and -N (T2) (T3); Z3 and Z4 are taken together to form an oxo group on the carbon atom to which they are attached; or Z3 and Z4 are each independently selected from the group consisting of H, -C1-6 alkyl, -OT1 and -N (T2) (T3); Z5 and Z6 are taken together to form an oxo group on the carbon atom to which they are attached; or Z5 and Z6 are each independently selected from the group consisting of H, -C1-6 alkyl, -OT1 and -N (T2) (T3); X4 is absent or is selected from the group consisting of -NR4-, -N (R4) (CH2) -, -C (> = O) NH- and -C (> = O) -; R4 is selected from H and -C 1-6 alkyl; Y1 is selected from the group consisting of H, -C 1-6 alkyl and a saturated or unsaturated aromatic carbocycle or heterocycle of 4 to 7 members, with the proviso that the point of attachment in said heterocycle is carbon if X4 is -NR4- or -C (> = O) NH-, wherein said -C1-6 alkyl is optionally substituted with one or more substituents independently selected from -OT1, -ST1, -N (T2) (T3) and a saturated heterocycle of 5 to 6 members, and wherein said saturated or unsaturated aromatic carbocycle or heterocycle of 4 to 7 members is optionally substituted with one or more substituents independently selected from F, Cl, Br, I, -C (> = O) H, -OT1 , -N (T2) (T3), -C (> = O) N (T2) (T3), -C (> = O) OT1, - ST1 and -C1-3 alkyl, wherein said -C1 alkyl 3 is optionally substituted with one or more substituents independently selected from -OT1 and -N (T2) (T3); T1, T2 and T3 are each independently selected from H and -C 1-6 alkyl optionally substituted with one or more substituents independently selected from -N (T5) (T6), -OT7, -ST7, nitro, cyano, -C ( > = O) OT7, - C (> = O) N (T5) (T6), -OC (> = O) N (T5) (T6), -S (> = O) 2T7, -S (> = O) 2OT8 and -S (> = O) 2N (T5) (T6); T4 is -C 1-6 alkyl optionally substituted with one or more substituents independently selected from -N (T5) (T6), -OT7, -ST7, nitro, cyano, -C (> = O) OT7, -C (> = O) N (T5) (T6), -OC (> = O) N (T5) (T6), -S (> = O) 2T8, -S (> = O) 2OT7 and -S (> = O) 2N (T5) (T6); T5, T6 and T7 are each independently selected from H and -C 1-6 alkyl optionally substituted with one or more substituents independently selected from amino, hydroxyl, thiol, nitro and cyano; and T8 is selected from -C 1-6 alkyl optionally substituted with one or more substituents independently selected from amino, hydroxyl, thiol, nitro and cyano; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2012-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 756.