| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fdaa64756184e715af6cb25ebc318917 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-24086
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6489
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate |
2013-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b84a8a51fcaa1c935ed67920bea63f48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e430c9246d4182fc08e81b2dcecf666
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8382e8bbfe4ecaf9e2561e2def1248c9 |
| publicationDate |
2017-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2627816-T3 |
| titleOfInvention |
Variants of the pro-domain of tace as a TNF-a inhibitor and its medical use |
| abstract |
An isolated polypeptide comprising a TNF-α converting enzyme pro-domain (TACE), the polypeptide being devoid of a catalytic domain of said TACE, said polypeptide comprising a modification of a site selected from the group consisting of R58, R56 and K57 which makes said polypeptide resistant to degradation with furin, the polypeptide being able to downregulate a TACE activity, wherein the numbering of said modification corresponds to that of the complete TACE enzyme. |
| priorityDate |
2012-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |